Pig liver esterase catalyzed hydrolysis of dimethyl and diethyl 2-methyl-2-(o-nitrophenoxy)malonates

被引：18

作者：

Breznik, M ^{[1
]}

Kikelj, D ^{[1
]}

机构：

[1] UNIV LJUBLJANA,FAC PHARM,LJUBLJANA 1000,SLOVENIA

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0957-4166(96)00535-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Pig liver esterase (PLE) catalyzed hydrolysis of dimethyl and diethyl 2-methyl-2-(o-nitrophenoxy)malonates affords (R)-monoethyl/monomethyl 2-methyl-2-(o-nitrophenoxy)malonates in moderate to good enantiomeric excesses (69-81%). These data indicate that the nitro group may be accommodated in the large hydrophobic pocket of the Jones active-site model of PLE. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：425 / 434

页数：10

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