Intermolecular oxidative enolate heterocoupling

被引：165

作者：

Baran, Phil S. ^{[1
]}

DeMartino, Michael P. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 42期

关键词：

C-C coupling; enolates; lignans; synthetic methods; total synthesis;

D O I：

10.1002/anie.200603024

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) No priming necessary: The intermolecular oxidative heterocoupling of imides and oxindoles to esters, ketones, and lactones is shown for the first time to be synthetically viable. Strategic use of the initial oxidation state of the reactants allows for the excision of prefunctionalization steps (halogenation, enol-silane formation) and allows for the concise synthesis of unsymmetrical lignans, such as (-)-bursehernin (1). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7083 / 7086

页数：4

共 27 条

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