Pancreatic adenocarcinoma: update on the surgical pathology of carcinomas of ductal origin and PanINs

被引：78

作者：

Hruban, Ralph H.

Fukushima, Noriyoshi

机构：

[1] Johns Hopkins Med Inst, Sol Goldman Pancreat Canc Res Ctr, Dept Pathol, Baltimore, MD 21231 USA

[2] Johns Hopkins Med Inst, Sol Goldman Pancreat Canc Res Ctr, Dept Oncol, Baltimore, MD 21231 USA

[3] Univ Tokyo, Dept Pathol, Tokyo, Japan

来源：

MODERN PATHOLOGY | 2007年 / 20卷

关键词：

pancreatic cancer; pancreas; precursor; pancreatic intraepithelial neoplasia;

D O I：

10.1038/modpathol.3800685

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Pancreatic cancer is the fourth leading cause of cancer death in the US. Most pancreatic cancers are infiltrating ductal adenocarcinomas. The careful application of well-defined morphologic criteria can be used to differentiate between infiltrating ductal adenocarcinoma and reactive glands. While most pancreatic cancers are ductal adenocarcinomas, a number of histologically defined variants have been described. These are important to recognize because they have distinct clinical pathologic features. Pancreatic intraepithelial neoplasia (PanIN) is the presumed precursor lesion to infiltrating ductal adenocarcinoma, and PanIN lesions can mimic infiltrating cancer.

引用

页码：S61 / S70

页数：10

共 60 条

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