Brain-derived neurotrophic factor in human platelets

被引：41

作者：

PliegoRivero, FB

Bayatti, N

Giannakoulopoulos, X

Glover, V

Bradford, HF

Stern, G

Sandler, M

机构：

[1] QUEEN CHARLOTTES & CHELSEA HOSP,DEPT CHEM PATHOL,LONDON W6 0XG,ENGLAND

[2] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,DEPT BIOCHEM,LONDON SW7 2AY,ENGLAND

[3] QUEEN CHARLOTTES & CHELSEA HOSP,DEPT PAEDIAT,LONDON W6 0XG,ENGLAND

[4] MIDDLESEX HOSP,WOOLAVINGTON PRIVATE PATIENTS WING,LONDON W1N 8AA,ENGLAND

来源：

BIOCHEMICAL PHARMACOLOGY | 1997年 / 54卷 / 01期

关键词：

brain-derived neurotrophic factor (BDNF); neurotrophins; human platelets; CELISA assay;

D O I：

10.1016/S0006-2952(97)00073-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A sensitive, capture enzyme-linked immunosorbent assay (CELISA) has been applied to the accurate and reproducible measurement of brain-derived neurotrophic factor (BDNF) protein in normal human blood platelets, a mean concentration of 1.03 +/- 0.04 ng (SEM)/mg of platelet protein being observed. The method, which requires only 10 ml brood, is now suitable for the investigation of a variety of clinical disorders. (C) 1997 Elsevier Science Inc.

引用

页码：207 / 209

页数：3

共 18 条

[1] PURIFICATION OF A NEW NEUROTROPHIC FACTOR FROM MAMMALIAN BRAIN [J].