Toll-like receptors and innate immunity

被引：981

作者：

Kumar, Himanshu

Kawai, Taro

Akira, Shizuo ^{[1
]}

机构：

[1] Osaka Univ, WPI Immunol Frontier Res Ctr, Host Def Lab, Suita, Osaka 5650871, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 388卷 / 04期

基金：

日本学术振兴会;

关键词：

Innate immunity; Pattern-recognition receptors; Toll-like receptors; Toll-like receptor signaling; PLASMACYTOID DENDRITIC CELLS; RESPIRATORY SYNCYTIAL VIRUS; TRIF-DEPENDENT PATHWAYS; PATHOGEN RECOGNITION; TLR4-MD-2; COMPLEX; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; CUTTING EDGE; RESPONSES; ACTIVATION;

D O I：

10.1016/j.bbrc.2009.08.062

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Toll-like receptors (TLRs) are evolutionarily conserved innate receptors expressed in various immune and non-immune cells of the mammalian host. TLRs play a crucial role in defending against pathogenic microbial infection through the induction of inflammatory cytokines and type I interferons. Furthermore, TLRs also play roles in shaping pathogen-specific humoral and cellular adaptive immune responses. In this review, we describe the recent advances in pathogen recognition by TLRs and TLR signaling. (C) 2009 Elsevier Inc. All rights reserved.

引用

收藏

页码：621 / 625

页数：5

相关论文

共 38 条

[1] Recognition of pathogen-associated molecular patterns by TLR family [J].

Akira, S ;

Hemmi, H .

IMMUNOLOGY LETTERS, 2003, 85 (02) :85-95

[2] Pathogen recognition and innate immunity [J].

Akira, S ;

Uematsu, S ;

Takeuchi, O .

CELL, 2006, 124 (04) :783-801

[3] The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA [J].

Allen, Irving C. ;

Scull, Margaret A. ;

Moore, Chris B. ;

Holl, Eda K. ;

McElvania-TeKippe, Erin ;

Taxman, Debra J. ;

Guthrie, Elizabeth H. ;

Pickles, Raymond J. ;

Ting, Jenny P. -Y. .

IMMUNITY, 2009, 30 (04) :556-565

[4] TLRs and innate immunity [J].

Beutler, Bruce A. .

BLOOD, 2009, 113 (07) :1399-1407

[5] MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus [J].

Bhoj, Vijay G. ;

Sun, Qinmiao ;

Bhoj, Elizabeth J. ;

Somers, Cynthia ;

Chen, Xiang ;

Torres, Juan-Pablo ;

Mejias, Asuncion ;

Gomez, Ana M. ;

Jafri, Hasan ;

Ramilo, Octavio ;

Chen, Zhijian J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (37) :14046-14051

[6] The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling [J].

Brinkmann, Melanie M. ;

Spooner, Eric ;

Hoebe, Kasper ;

Beutler, Bruce ;

Ploegh, Hidde L. ;

Kim, You-Me .

JOURNAL OF CELL BIOLOGY, 2007, 177 (02) :265-275

[7] Live Borrelia burgdorferi Spirochetes Elicit Inflammatory Mediators from Human Monocytes via the Toll-Like Receptor Signaling Pathway [J].

Dennis, Vida A. ;

Dixit, Saurabh ;

O'Brien, Shannon M. ;

Alvarez, Xavier ;

Pahar, Bapi ;

Philipp, Mario T. .

INFECTION AND IMMUNITY, 2009, 77 (03) :1238-1245

[8]

Ewald SE, 2008, NATURE, V456, P658, DOI 10.1038/nature07405

[9] The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis [J].

Franchi, Luigi ;

Eigenbrod, Tatjana ;

Munoz-Planillo, Raul ;

Nunez, Gabriel .

NATURE IMMUNOLOGY, 2009, 10 (03) :241-247

[10] Inflammasome recognition of influenza virus is essential for adaptive immune responses [J].

Ichinohe, Takeshi ;

Lee, Heung Kyu ;

Ogura, Yasunori ;

Flavell, Richard ;

Iwasaki, Akiko .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (01) :79-87

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