A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells

被引：141

作者：

Williams, BP

Park, JK

Alberta, JA

Muhlebach, SG

Hwang, GY

Roberts, TM

Stiles, CD

机构：

[1] HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOL GENET,CAMBRIDGE,MA 02138

[2] HARVARD UNIV,SCH MED,DEPT PATHOL,CAMBRIDGE,MA 02138

[3] DANA FARBER CANC INST,BOSTON,MA

[4] HARVARD UNIV,SCH MED,DEPT NEUROSURG,BOSTON,MA 02115

[5] CHILDRENS HOSP,BOSTON,MA 02115

来源：

NEURON | 1997年 / 18卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0896-6273(00)80297-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

When exposed to platelet-derived growth factor (PDGF), uncommitted neuroepithelial cells from the developing cortex of embryonic day 14 (E14) rats develop into neurons. Outward signs of the neuronal phenotype are not observed for 4 days following exposure to PDGF. However, only a brief (23 hr) period of PDGF receptor activation is required to initiate neuronal development. During the window of receptor activation, RNA synthesis is essential, but protein synthesis is not. These observations indicate that specification of neuronal fate is mediated by an immediate early gene response.

引用

页码：553 / 562

页数：10

共 62 条

[1]

AKAZAWA C, 1992, J BIOL CHEM, V267, P21879

[2] THE NEURAL CREST CELL LINEAGE PROBLEM - NEUROPOIESIS [J].