Cerebral ischaemia: tomorrow's therapeutic tracks

被引：6

作者：

Bordet, Regis ^{[1
]}

Ouk, Thavarak ^{[1
]}

Onteniente, Brigitte ^{[2
]}

Charriaut-Marlangue, Christiane ^{[3
]}

Heurteaux, Catherine ^{[4
]}

机构：

[1] Univ Lille Nord France, EA1046, Dept Med Pharmacol, Inst Med Predict & Rech Therapeut,Fac Med,Ctr Hos, F-59037 Lille, France

[2] I Stem, U861, F-91030 Evry, France

[3] Univ Paris 06, CNRS, UMR 7102, Fac Sci Jussieu, Paris, France

[4] Univ Nice Sophia Antipolis, UMR 6097, Inst Pharmacol Mol & Cellulaire, CNRS, Valbonne, France

来源：

M S-MEDECINE SCIENCES | 2009年 / 25卷 / 10期

关键词：

PHARMACOLOGICAL TARGET; NEUROVASCULAR UNIT; STROKE SEVERITY; NEUROPROTECTION; INHIBITOR; TOLERANCE; INJURY; CELLS; XIAP;

D O I：

10.1051/medsci/20092510847

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cerebral ischaemia: tomorrow's therapeutic tracks Thrombolysis remains the main therapeutic strategy used in stroke, but with a limited use to only a part of stroke patients. A neuroprotective approach would be necessary with a double objective : (1) to serve as an add-on treatment with thrombolysis to improve safety and increase therapeutic window; (2) to limit infarct area by delaying neuronal death. While numerous molecules failed in clinical trials in stroke, pharmacological development is ongoing with pleiotropic drugs targeting both neuronal and vascular ports of neurovascular unit. Another approach targets the functional rehabilitation and the neurorepair using pharmacological ways or cell therapy.

引用

页码：847 / 854

页数：8

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