Circulating tumor cells in breast cancer

被引：199

作者：

Bidard, Francois-Clement ^{[1
,2
]}

Proudhon, Charlotte ^{[1
]}

Pierga, Jean-Yves ^{[1
,2
,3
]}

机构：

[1] PSL Res Univ, Inst Curie, SiRIC, Lab Circulating Tumor Biomarkers, F-75005 Paris, France

[2] PSL Res Univ, Inst Curie, Dept Med Oncol, 26 Rue Ulm, F-75005 Paris, France

[3] Univ Paris 05, Paris, France

来源：

MOLECULAR ONCOLOGY | 2016年 / 10卷 / 03期

关键词：

Breast cancer; Circulating tumor cells; Prognostic markers; Metastatic process; BONE-MARROW MICROMETASTASIS; GENE-EXPRESSION PROFILES; PIK3CA MUTATIONAL STATUS; RNA-POSITIVE CELLS; PERIPHERAL-BLOOD; MESSENGER-RNA; PROGNOSTIC-SIGNIFICANCE; MESENCHYMAL TRANSITION; CLINICAL-SIGNIFICANCE; PROMOTER METHYLATION;

D O I：

10.1016/j.molonc.2016.01.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Over the past decade, technically reliable circulating tumor cell (CTC) detection methods allowed the collection of large datasets of CTC counts in cancer patients. These data can be used either as a dynamic prognostic biomarker or as tumor material for "liquid biopsy". Breast cancer appears to be the cancer type in which CTC have been the most extensively studied so far, with level-of-evidence-1 studies supporting the clinical validity of CTC count in both early and metastatic stage. This review summarizes and discusses the clinical results obtained in breast cancer patients, the issues faced by the molecular characterization of CTC and the biological findings about cancer biology and metastasis that were obtained from CTC. (C) 2016 The Authors. Published by Elsevier B.V. on behalf of Federation of European Biochemical Societies.

引用

页码：418 / 430

页数：13

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