The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing

被引：586

作者：

Deng, Liling ^{[1
]}

Du, Chenzhen ^{[1
]}

Song, Peiyang ^{[1
]}

Chen, Tianyi ^{[1
]}

Rui, Shunli ^{[1
]}

Armstrong, David G. ^{[2
]}

Deng, Wuquan ^{[1
]}

机构：

[1] Chongqing Univ, Multidisciplinary Diabet Foot Med Ctr, Chongqing Emergency Med Ctr, Dept Endocrinol,Cent Hosp, Chongqing 400014, Peoples R China

[2] Univ Southern Calif, Dept Surg, Keck Sch Med, Los Angeles, CA 90007 USA

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2021年 / 2021卷

基金：

美国国家卫生研究院;

关键词：

Compendex;

D O I：

10.1155/2021/8852759

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Foot ulcers are one of the most common and severe complication of diabetes mellitus with significant resultant morbidity and mortality. Multiple factors impair wound healing include skin injury, diabetic neuropathy, ischemia, infection, inadequate glycemic control, poor nutritional status, and severe morbidity. It is currently believed that oxidative stress plays a vital role in diabetic wound healing. An imbalance of free radicals and antioxidants in the body results in overproduction of reactive oxygen species which lead to cell, tissue damage, and delayed wound healing. Therefore, decreasing ROS levels through antioxidative systems may reduce oxidative stress-induced damage to improve healing. In this context, we provide an update on the role of oxidative stress and antioxidants in diabetic wound healing through following four perspectives. We then discuss several therapeutic strategies especially dietary bioactive compounds by targeting oxidative stress to improve wounds healing.

引用

页数：11

共 110 条

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Effect of Daptomycin on Local Interleukin-6, Matrix Metalloproteinase-9, and Metallopeptidase Inhibitor 1 in Patients With MRSA-Infected Diabetic Foot [J].