Transmission of Drug-Resistant HIV-1 Is Stabilizing in Europe

被引：202

作者：

Vercauteren, Jurgen ^{[2
]}

Wensing, Annemarie M. J.

van de Vijver, David A. M. C. ^{[3
]}

Albert, Jan ^{[4
,5
]}

Balotta, Claudia ^{[7
]}

Hamouda, Osamah ^{[8
]}

Kuecherer, Claudia ^{[8
]}

Struck, Daniel ^{[10
,11
]}

Schmit, Jean-Claude ^{[10
,11
]}

Asjo, Birgitta ^{[12
]}

Bruckova, Marie ^{[13
]}

Camacho, Ricardo J. ^{[14
,15
]}

Clotet, Bonaventura ^{[16
]}

Coughlan, Suzie ^{[17
]}

Grossman, Zehava ^{[18
]}

Horban, Andrzej ^{[19
]}

Korn, Klaus ^{[9
]}

Kostrikis, Leondios ^{[20
]}

Nielsen, Claus ^{[21
]}

Paraskevis, Dimitrios ^{[22
]}

Poljak, Mario ^{[23
]}

Puchhammer-Stoeckl, Elisabeth ^{[24
]}

Riva, Chiara ^{[7
]}

Ruiz, Lidia ^{[16
]}

Salminen, Mika ^{[25
]}

Schuurman, Rob

Sonnerborg, Anders ^{[6
]}

Stanekova, Danica ^{[26
]}

Stanojevic, Maja

Vandamme, Anne-Mieke ^{[2
]}

Boucher, Charles A. B. ^{[1
,3
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Med Microbiol, NL-3584 CX Utrecht, Netherlands

[2] Katholieke Univ Leuven, Leuven, Belgium

[3] Erasmus MC, Rotterdam, Netherlands

[4] Karolinska Inst, Swedish Inst Infect Dis Control, Dept Virol, Stockholm, Sweden

[5] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden

[6] Karolinska Univ Hosp, Stockholm, Sweden

[7] Univ Milan, Milan, Italy

[8] Robert Koch Inst, D-1000 Berlin, Germany

[9] Univ Erlangen Nurnberg, Erlangen, Germany

[10] Ctr Hosp Luxembourg, Luxembourg, Luxembourg

[11] Ctr Rech Publ Sante, Luxembourg, Luxembourg

[12] Univ Bergen, Gade Inst, Bergen, Norway

[13] Natl Inst Publ Hlth, Prague, Czech Republic

[14] Ctr Hosp Lisboa Ocidental, Lisbon, Portugal

[15] Inst Higiene & Med Trop, Lisbon, Portugal

[16] IRSICAIXA Fdn, Retrovirol Lab, Badalona, Spain

[17] Univ Coll Dublin, Dublin 2, Ireland

[18] Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel

[19] Warsaw Med Univ & Hosp Infect Dis, Warsaw, Poland

[20] Univ Cyprus, Nicosia, Cyprus

[21] Statens Serum Inst, Copenhagen, Denmark

[22] Univ Athens, Sch Med, GR-11527 Athens, Greece

[23] Univ Ljubljana, Ljubljana, Slovenia

[24] Med Univ Vienna, Vienna, Austria

[25] Natl Publ Hlth Inst, Helsinki, Finland

[26] Slovak Med Univ, Bratislava, Slovakia

来源：

JOURNAL OF INFECTIOUS DISEASES | 2009年 / 200卷 / 10期

基金：

瑞典研究理事会;

关键词：

DECLINING PREVALENCE; MUTATIONS; PATTERNS;

D O I：

10.1086/644505

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The SPREAD Programme investigated prospectively the time trend from September 2002 through December 2005 of transmitted drug resistance (TDR) among 2793 patients in 20 European countries and in Israel with newly diagnosed human immunodeficiency virus type 1 (HIV-1) infection. The overall prevalence of TDR was 8.4% (225 of 2687 patients; 95% confidence interval [CI], 7.4%-9.5%), the prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) resistance was 4.7% (125 of 2687 patients; 95% CI, 3.9%-5.5%), the prevalence of nonucleoside reverse-transcriptase inhibitor (NNRTI) resistance was 2.3% (62 of 2687 patients; 95% CI, 1.8%-2.9%), and the prevalence of protease inhibitor (PI) resistance was 2.9% (79 of 2687 patients; 95% CI, 2.4%-3.6%). There was no time trend in the overall TDR or in NRTI resistance, but there was a statistically significant decrease in PI resistance (P = .04) and in NNRTI resistance after an initial increase (P = .02). We found that TDR appears to be stabilizing in Europe, consistent with recent reports of decreasing drug resistance and improved viral suppression in patients treated for HIV-1 infection.

引用

页码：1503 / 1508

页数：6

共 15 条

[1] Transmitted drug resistant HIV-1 and association with virologic and CD4 cell count response to combination Antiretroviral therapy in the EuroSIDA study [J].

Bannister, Wendy P. ;

Cozzi-Lepri, Alessandro ;

Clotet, Bonaventura ;

Mocroft, Amanda ;

Kjaer, Jesper ;

Reiss, Peter ;

von Wyl, Viktor ;

Lazzarin, Adriano ;

Katlama, Christine ;

Phillips, Andrew N. ;

Ruiz, Lidia ;

Lundgren, Jens D. .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2008, 48 (03) :324-333

[2] Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 Update [J].

Bennett, Diane E. ;

Camacho, Ricardo J. ;

Otelea, Dan ;

Kuritzkes, Daniel R. ;

Fleury, Herve ;

Kiuchi, Mark ;

Heneine, Walid ;

Kantor, Rami ;

Jordan, Michael R. ;

Schapiro, Jonathan M. ;

Vandamme, Anne-Mieke ;

Sandstrom, Paul ;

Boucher, Charles A. B. ;

van de Vijver, David ;

Rhee, Soo-Yon ;

Liu, Tommy F. ;

Pillay, Deenan ;

Shafer, Robert W. .

PLOS ONE, 2009, 4 (03)

[3] Prevalence and predictors of antiretroviral drug resistance in newly diagnosed HIV-1 infection [J].

Booth, Clare L. ;

Garcia-Diaz, Ana M. ;

Youle, Michael S. ;

Johnson, Margaret A. ;

Phillips, Andrew ;

Geretti, Anna Maria .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 59 (03) :517-524

[4] Changing rates and patterns of drug resistance mutations in antiretroviral-experienced HIV-infected patients [J].

De Mendoza, Carmen ;

Garrido, Carolina ;

Corral, Angelica ;

Ramirez-Olivencia, German ;

Jimenez-Nacher, Inmaculada ;

Zahonero, Natalia ;

Gonzalez-Lahoz, Juan ;

Soriano, Vincent .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2007, 23 (07) :879-885

[5] An automated genotyping system for analysis of HIV-1 and other microbial sequences [J].

de Oliveira, T ;

Deforche, K ;

Cassol, S ;

Salminen, M ;

Paraskevis, D ;

Seebregts, C ;

Snoeck, J ;

van Rensburg, EJ ;

Wensing, AMJ ;

van de Vijver, DA ;

Boucher, CA ;

Camacho, R ;

Vandamme, AM .

BIOINFORMATICS, 2005, 21 (19) :3797-3800

[6]

Di Giambenedetto S, 2007, ANTIVIR THER, V12, P835

[7]

Dunn D, 2008, ANTIVIR THER, V13, P771

[8]

Hogg R, 2008, LANCET, V372, P293, DOI 10.1016/S0140-6736(08)61113-7

[9] Minority HIV-1 drug resistance mutations are present in antiretroviral treatment-naive populations and associate with reduced treatment efficacy [J].

Johnson, Jeffrey A. ;

Li, Jin-Fen ;

Wei, Xierong ;

Lipscomb, Jonathan ;

Irlbeck, David ;

Craig, Charles ;

Smith, Amanda ;

Bennett, Diane E. ;

Monsour, Michael ;

Sandstrom, Paul ;

Lanier, E. Randall ;

Heneine, Walid .

PLOS MEDICINE, 2008, 5 (07) :1112-1122

[10] Antiretroviral-drug resistance among patients recently infected with HIV [J].

Little, SJ ;

Holte, S ;

Routy, JP ;

Daar, ES ;

Markowitz, M ;

Collier, AC ;

Koup, RA ;

Mellors, JW ;

Connick, E ;

Conway, B ;

Kilby, M ;

Wang, L ;

Whitcomb, JM ;

Hellmann, NS ;

Richman, DD .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (06) :385-394

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