How to flip the (redox) switch

被引：125

作者：

Georgiou, G ^{[1
]}

机构：

[1] Univ Texas, Dept Chem Engn, Austin, TX 78712 USA

[2] Univ Texas, Dept Biomed Engn, Austin, TX 78712 USA

[3] Univ Texas, Inst Cell & Mol Biol, Austin, TX 78712 USA

来源：

CELL | 2002年 / 111卷 / 05期

关键词：

D O I：

10.1016/S0092-8674(02)01165-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Redox-sensitive transcription factors such as the E. coli OxyR and S. cerevisiae Yap1, are activated by conformational changes that stem from the posttranslational modification of reactive protein thiols. Recent studies provide new insights on how different agents that cause redox stress mediate the activation of transcription through distinct and specific pathways.

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页码：607 / 610

页数：4

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