Tissue factor-positive microparticles: Cellular origin and association with coagulation activation in patients with colorectal cancer

被引:248
作者
Hron, Gregor
Kollars, Marietta
Weber, Heinz
Sagaster, Verena
Quehenberger, Peter
Eichinger, Sabine
Kyrle, Paul A.
Weltermann, Ansgar
机构
[1] Med Univ Vienna, Dept Internal Med 1, A-1090 Vienna, Austria
[2] Med Univ Vienna, Inst Clin Med, A-1090 Vienna, Austria
[3] Med Univ Vienna, Chem Lab Diagnost, A-1090 Vienna, Austria
关键词
cancer; microparticles; tissue factor; hemostasis; platelets;
D O I
10.1160/TH06-03-0141
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The pathogenesis of hypercoagulability in cancer is not entirely understood. We hypothesized that in cancer patients circulating tissue factor-positive microparticles (TF+ MPs) are increased and associated with hemostatic system activation. In 20 patients with advanced colorectal cancer and in 20 age- and sex-matched controls, number and cellular origin of TF+ MPs were determined in plasma by flow cytometry. D-dimer was determined as an indicator of hemostatic system activation. Compared to controls, the median (interquartile range) number of TF+ MPs was two-fold higher in cancer patients: 25.9 (15.4 - 42.0) x 10(3)/ml plasma versus 13.1 (11.9 - 19.7) x 10(3)/ml plasma, p = 0.007. This was mainly due to a higher amount of TF+ MPs from platelets (13.4 [5.0 - 17.4] x 10(3)/ml plasma vs. 5.8 [4.5 - 7.5] x 10(3)/ml plasma, p = 0.017). TF+ MPs correlated with D-dimer (p = 0.48, p = 0.002). High levels of TF+ MPs in cancer patients and their correlation with D-climer suggest that TF+ MPs might be involved in hemostasis activation in cancer patients.
引用
收藏
页码:119 / 123
页数:5
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