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Antihypertensive and antioxidant effects of the Graptopetalum paraguayense E. Walther extract in spontaneously hypertensive rats

被引：12
作者：
Chung, Yun-Chin [1 ]
Chen, Shu-Ju [1 ,2 ]
Peng, Hsin-Yi [1 ]
Chou, Su-Tze [1 ]
机构：
[1] Providence Univ, Dept Food & Nutr, Shalu, Taichung Hsien, Taiwan
[2] Chung Chou Inst Technol, Dept Nutr & Hlth Sci, Changhua, Changhua County, Taiwan
来源：
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE | 2009年 / 89卷 / 15期
关键词：
Graptopetalum paraguayense E. Walther; spontaneously hypertensive rats (SHR); blood pressure; antioxidants; angiotensin I converting enzyme (ACE); ANGIOTENSIN-CONVERTING ENZYME; PERFORMANCE LIQUID-CHROMATOGRAPHY; OXIDATIVE STRESS; FREE-RADICALS; GLUTATHIONE; TOCOPHEROL; CAPTOPRIL; PLASMA; TISSUE; MICE;
D O I：
10.1002/jsfa.3774
中图分类号：
S [农业科学];
学科分类号：
082806 [农业信息与电气工程];
摘要：
BACKGROUND: Our previous in vitro study showed that 50% ethanolic extract of Graptopetalum paraguayense E. Walther (GE50) exhibited an inhibitory effect on angiotensin I converting enzyme (ACE). This study was aimed at evaluating the antihypertensive and antioxidant effects of GE50 extract on spontaneously hypertensive rats (SHR). RESULTS: Daily oral administration of GE50 extract (2.5 g kg(-1) body weight) for 4 weeks exhibited a significant decrease in blood pressure as well as ACE activity of tested tissues in SHR rats, while no significant change was found in normotensive Wistar Kyoto rats (WKY). For SHR, GE50 extract increased the total antioxidant status in the plasma and decreased malondialdehyde levels in all tested tissues. Furthermore, GE50 extract increased alpha-tocopherol and glutathione levels in brain tissue, glutathione peroxidase and catalase activities in heart, as well as catalase activity in liver tissue. In WKY rats, GE50 extract only increased ascorbic acid level in liver tissue. CONCLUSION: The present study demonstrated that GE50 might serve as an antioxidant and an ACE inhibitor in convalescence from hypertension in rats. (C) 2009 Society of Chemical Industry
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页码：2678 / 2686
页数：9
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