In Vivo Assessment of the Antimicrobial Activity of a Calcium-Deficient Apatite Vancomycin Drug Delivery System in a Methicillin-Resistant Staphylococcus aureus Rabbit Osteomyelitis Experimental Model

被引：10

作者：

Amador, G. ^{[1
,2
,3
]}

Gautier, H. ^{[4
]}

Le Mabecque, V. ^{[1
,3
]}

Miegeville, A. F. ^{[1
,3
]}

Potel, G. ^{[1
,2
,3
]}

Bouler, J. -M. ^{[4
]}

Weiss, P. ^{[4
]}

Caillon, J. ^{[1
,2
,3
]}

Jacqueline, C. ^{[1
,3
]}

机构：

[1] Fac Med, EA 3826, UPRES, UFR Med, F-44035 Nantes, France

[2] CHU Nantes, F-44035 Nantes, France

[3] Univ Nantes, F-44035 Nantes, France

[4] INSERM, UMRS 791, Lab Osteoarticular & Dent Tissue Engn 1, F-44042 Nantes, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 02期

关键词：

INFECTIONS; MANAGEMENT; BONE;

D O I：

10.1128/AAC.00434-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

The antimicrobial activities of calcium-deficient apatite loaded with different concentrations (25, 100, and 500 mu g/mg) of vancomycin as a filling biomaterial were evaluated in a methicillin-resistant Staphylococcus aureus (MRSA) rabbit acute osteomyelitis model. Bacterial counts in bone, bone marrow, and joint fluid samples treated with forms of the apatite were compared to those in tissue samples receiving a constant intravenous vancomycin infusion after 4 days. This study demonstrates that using a calcium-deficient apatite loaded with vancomycin dramatically decreases the bacterial counts in bone and marrow.

引用

页码：950 / 952

页数：3

共 12 条

[1]

Berberich E., 2005, P 21 ANN S COMP GEOM, P99

[2]

Calcium-deficient apatite:: A first in vivo study concerning bone ingrowth [J].