Localization of 5-HT6 receptors at the plasma membrane of neuronal cilia in the rat brain

被引：183

作者：

Brailov, I

Bancila, M

Brisorgueil, MJ

Miquel, MC

Hamon, M

Vergé, D

机构：

[1] Univ Paris 06, Inst Neurosci, Lab Neurobiol Signaux Intercellulaires, CNRS,UMR 7624, F-75005 Paris, France

[2] CHU Pitie Salpetriere, INSERM, U288, Unite Neuropsychopharmacol, F-75634 Paris 13, France

来源：

BRAIN RESEARCH | 2000年 / 872卷 / 1-2期

关键词：

5-HT6; receptors; Islands of Calleja; Neuronal cilia; immunocytochemistry; subcellular localization;

D O I：

10.1016/S0006-8993(00)02519-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

5-HT6 receptor-like immunoreactivity has been previously found in association with both neuronal dendrites and cilia in the striatum, nucleus accumbens, olfactory tubercle and islands of Calleja of the rat brain. Using immunogold pre-embedding immunocytochemical techniques to investigate the subcellular localization of 5-HT6 receptor-like immunoreactivity in cilia, we showed that immunogold particles were associated with their plasma membrane, and not with microtubules. This membrane localization is consistent with a possible physiological role, which is still unknown, of these receptors. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：271 / 275

页数：5

共 15 条

[1]

Baumgarten H. G., 1997, HDB EXPT PHARM, V129

[2]

BAYER VE, 1990, J NEUROSCI, V10, P2996

[3]

Berry SA, 1996, MOL PHARMACOL, V50, P306

[4]

Calas A., 1978, 3 INT S WURZBURGBRAI, P238

[5]

Immuno-localization of serotonin 5-HT6 receptor-like material in the rat central nervous system [J].

Gerard, C ;

Martres, MP ;

Lefevre, K ;

Miquel, MC ;

Verge, D ;

Lanfumey, L ;

Doucet, E ;

Hamon, M ;

ElMestikawy, S .

BRAIN RESEARCH, 1997, 746 (1-2) :207-219

[6]

Antibodies and antisense oligonucleotide for probing the distribution and putative functions of central 5-HT6 receptors [J].

Hamon, M ;

Doucet, E ;

Lefevre, K ;

Miquel, MC ;

Lanfumey, L ;

Insausti, R ;

Frechilla, D ;

Del Rio, J ;

Vergé, D .

NEUROPSYCHOPHARMACOLOGY, 1999, 21 (02) :S68-S76

[7]

Selective targeting of somatostatin receptor 3 to neuronal cilia [J].

Händel, M ;

Schulz, S ;

Stanarius, A ;

Schreff, M ;

Erdtmann-Vourliotis, M ;

Schmidt, H ;

Wolf, G ;

Höllt, V .

NEUROSCIENCE, 1999, 89 (03) :909-926

[8]

3-DIMENSIONAL STUDIES OF NEURONS IN LATERAL GENICULATE NUCLEUS OF RAT .2. ENVIRONMENT OF PERIKARYA AND PROXIMAL PARTS OF THEIR BRANCHES [J].

KARLSSON, U .

JOURNAL OF ULTRASTRUCTURE RESEARCH, 1966, 16 (5-6) :482-+

[9]

MONSMA FJ, 1993, MOL PHARMACOL, V43, P320

[10]

Anxiogenic-like effects and reduced stereological counting of immunolabelled 5-hydroxytryptamine6 receptors in rat nucleus accumbens by antisense oligonucleotides [J].

Otano, A ;

Frechilla, D ;

Cobreros, A ;

Cruz-Orive, LM ;

Insausti, A ;

Insausti, R ;

Hamon, M ;

Del Rio, J .

NEUROSCIENCE, 1999, 92 (03) :1001-1009

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