The peripheral benzodiazepine receptors: a review

被引：84

作者：

Beurdeley-Thomas, A

Miccoli, L

Oudard, S

Dutrillaux, B

Poupon, MF

机构：

[1] Inst Curie, CNRS, UMR 147, Lab Cytogenet Mol & Oncol, F-75248 Paris 05, France

[2] CEA Fontenay, DSV DRR LGR, Lab Genet Radiosensibil, Fontenay Aux Roses, France

来源：

JOURNAL OF NEURO-ONCOLOGY | 2000年 / 46卷 / 01期

关键词：

PBR; associated proteins; PRAX-1; cell differentiation; cancer; steroid biosynthesis;

D O I：

10.1023/A:1006456715525

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Peripheral benzodiazepine receptors (PBRs) have been identified in various peripheral tissues as well as in glial cells in the brain. This review describes the tissue and subcellular distribution of the PER in mammalian tissues and analyzes its many putative endogenous ligands. It deals with the pharmacological, structural and molecular characterization of the PER, the proteins associated with the receptor (VDAC, ANC, PRAX-1) and their roles in cell growth and differentiation, cancer, steroid biosynthesis, and other physiological roles.

引用

页码：45 / 56

页数：12

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