Intramyocellular lipid and insulin resistance -: A longitudinal in vivo 1H-spectroscopic study in Zucker diabetic fatty rats

被引：104

作者：

Kuhlmann, J ^{[1
]}

Neumann-Haefelin, C ^{[1
]}

Belz, U ^{[1
]}

Kalisch, J ^{[1
]}

Juretschke, HP ^{[1
]}

Stein, M ^{[1
]}

Kleinschmidt, E ^{[1
]}

Kramer, W ^{[1
]}

Herling, AW ^{[1
]}

机构：

[1] Aventis Pharma Deutschland GmbH, Dis Grp Metab Dis, Pharmacol H 815H 821, D-65926 Frankfurt, Germany

来源：

DIABETES | 2003年 / 52卷 / 01期

关键词：

D O I：

10.2337/diabetes.52.1.138

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin resistance plays an important role in the pathogenesis of human type 2 diabetes. In humans, a negative correlation between insulin sensitivity and intramyocellular lipid (IMCL) content has been shown; thus, IMCL becomes a marker for insulin resistance. Recently, magnetic resonance spectroscopy (MRS) has been established as a dependable method for selective detection and quantification of IMCL in humans. To validate the interrelation between insulin sensitivity and IMCL in an animal model of type 2 diabetes, we established volume selective H-1-MRS at 7 Tesla to noninvasively assess IMCL in the rat. In male obese Zucker Diabetic Fatty rats and their lean littermates, IMCL levels were determined repeatedly over 4 months, and insulin sensitivity was measured by the euglycemic-hyperinsulinemic clamp method at 6-7 and at 22-24 weeks of age. A distinct relation between IMCL and insulin sensitivity was demonstrated as well as age dependence for both parameters. Rosiglitazone treatment caused a clear reduction of IMCL and hepatic fat despite increased body weight, and a marked improvement of insulin sensitivity. Thus, the insulin sensitizing properties of rosiglitazone were consistent with a redistribution of lipids from nonadipocytic (skeletal muscle, liver) back into fat tissue.

引用

页码：138 / 144

页数：7

共 48 条

[1] Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans [J].