Perforant pathway kindling transiently induces the mRNA expression of GABA-B receptor subtypes R1A and R2 in the adult rat hippocampus

被引:10
作者
Francis, J
Jung, BP
Zhang, GM
Ho, W
Cheng, J
Burnham, WM
Eubanks, JH
机构
[1] Toronto Western Res Inst, Univ Hlth Network, Div Cellular & Mol Biol, Toronto, ON M5T 2S8, Canada
[2] Univ Toronto, Bloorview Epilepsy Res Program, Toronto, ON M5S 1A8, Canada
[3] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A8, Canada
[4] Univ Toronto, Dept Surg Neurosurg, Toronto, ON M5S 1A8, Canada
[5] Univ Toronto, Dept Pharmacol, Toronto, ON M5S 1A8, Canada
来源
MOLECULAR BRAIN RESEARCH | 2001年 / 91卷 / 1-2期
基金
加拿大健康研究院;
关键词
kindling; gene expression; GABA-B receptor; hippocampus;
D O I
10.1016/S0169-328X(01)00122-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We examined the gene expression responses of GABA-B R1A, R1B and R2 receptor subtypes in the hippocampus of perforant pathway-kindled rats at 24 h and 28 days after 15 consecutive daily stimulations. We found RIA expression, but not RIB expression, to be significantly induced in the dentate gyrus at 24 h. No change in the expression of RIA or RIB was observed at 28 days. R2 expression was induced throughout the hippocampus at 24 h, but also returned to control levels by 28 days. Thus, our results show that kindling induces a transient increase in GABA-B receptor mRNA in the hippocampus. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:159 / 162
页数:4
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