UDP-sugar transporter implicated in glycosylation and processing of Notch

被引：106

作者：

Goto, S

Taniguchi, M

Muraoka, M

Toyoda, H

Sado, Y

Kawakita, M

Hayashi, S

机构：

[1] Grad Univ Adv Studies, Dept Genet, Mishima, Shizuoka 4118540, Japan

[2] Tokyo Metropolitan Inst Med Sci, Dept Physiol Chem, Bunkyo Ku, Tokyo 1138613, Japan

[3] Chiba Univ, Fac Pharmaceut Sci, Div Analyt Sci, Chiba 2638522, Japan

[4] RIKEN, Ctr Dev Biol, Mishima, Shizuoka 4118540, Japan

[5] Natl Inst Genet, Genet Strain Res Ctr, Mishima, Shizuoka 4118540, Japan

来源：

NATURE CELL BIOLOGY | 2001年 / 3卷 / 09期

关键词：

D O I：

10.1038/ncb0901-816

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Glycosylation modifies protein activities in various biological processes. Here, we report the functions of a novel UDP-sugar transporter (UST74C, an alternative name for Fringe connection (Frc)) localized to the Golgi apparatus in cellular signalling of Drosophila. Mutants in the frc gene exhibit phenotypes resembling wingless and Notch mutants. Both Fringe-dependent and Fringe-independent Notch pathways are affected, and both glycosylation and proteolytic maturation of Notch are defective in mutant larvae. The results suggest that changes in nucleotide-sugar levels can differently affect Wingless and two distinct aspects of Notch signalling.

引用

页码：816 / 822

页数：7

共 51 条

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