Identification of multiple copies of a 20q-chromosome in a case of myelodysplastic syndrome: a FISH study

被引：8

作者：

Falzetti, D

Vermeesch, JR

Hood, TL

Nacheva, EP

Matteucci, C

Martelli, MF

Van den Berghe, H

Marynen, P

Mecucci, C ^{[1
]}

机构：

[1] Univ Perugia, Hematol & Bone Marrow TRansplantat Unit, Monteluce Policlin, I-06100 Perugia, Italy

[2] Katholieke Univ Leuven, Interuniv Inst Biotechnol, Louvain, Belgium

[3] Katholieke Univ Leuven, Ctr Human Genet, Louvain, Belgium

[4] Univ Cambridge, Dept Haematol, Cambridge CB2 1TN, England

来源：

LEUKEMIA RESEARCH | 1999年 / 23卷 / 04期

关键词：

karyotypic markers; chromosome microdissection; FISH; 20q-chromosome; MDS;

D O I：

10.1016/S0145-2126(98)00177-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In myelodysplastic syndromes (MDS) karyotypic aberrations identify subgroups of patients with distinct clinical-morphological features and can be relevant in risk assessment of developing leukemia. Often conventional cytogenetic analysis is not sufficiently informative due to the presence of partially or completely unrecognizable chromosome markers. By chromosome microdissection (MD) and fluorescence in situ hybridization (FISH) we investigated the nature of a karyotypic marker occurring in multiple copies in one case of MDS arisen in a patient previously treated for breast cancer. Results showed dicentrics derived from telomeric fusion between interstitially deleted 20q-chromosomes. The abnormal karyotype resulted into polysomy for a deleted chromosome 20q. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：407 / 413

页数：7

共 24 条

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