Isoprostanes, biomarkers of lipid peroxidation in humans. Part 3: Biomarkers and mediators in vascular physiology and disease

The 15-series F-2-isoprostanes mediate vasoconstriction in different vascular beds and species. This contraction is mediated by the thromboxane receptors stimulation, and may be modulated by the endothelium. Furthermore, 15-F-2t-IsoP induces smooth muscle cells mitogenesis and monocyte adhesion to endothelial cells. Some 15-series E-2-isoprostanes are more potent than F2-isoprostanes. In clinical studies, 15-F-2t-IsoP levels are increased in vascular disorders involving atherosclerosis, ischemia-reperfusion and inflammation. F-2-isoprostane levels correlate to the severity of heart failure and pulmonary hypertension, raising the potential prognostic interest of these biomarkers. Whether the effects observed in vitro are observed consistently in vivo at physiological concentrations and whether these effects contribute to pathological states in vivo is still debated. (c) 2004 Elsevier SAS. Tous droits reserves.