Room temperature hydroalkylation of electron-deficient olefins:: sp3 C-H functionalization via a Lewis acid-catalyzed intramolecular redox event

被引：211

作者：

Pastine, SJ ^{[1
]}

McQuaid, KM ^{[1
]}

Sames, D ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 35期

关键词：

D O I：

10.1021/ja053337f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A practical method for the intramolecular hydroalkylation of electron-deficient olefins has been developed. The direct transformation of benzylic, tertiary, and sterically hindered secondary sp3 C-H bonds into C-C bonds under the action of a catalytic amount of a variety of Lewis acids is described. The mechanism of these transformations is proposed to involve a tandem hydride transfer/cyclization sequence. Copyright © 2005 American Chemical Society.

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页码：12180 / 12181

页数：2

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