Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization

被引:14
作者
DesGroseillers, L
Lemieux, N
机构
[1] UNIV MONTREAL,DEPT PATHOL,MONTREAL,PQ H3C 3J7,CANADA
[2] HOP ST JUSTINE,CTR RECH,MONTREAL,PQ H3T 1C5,CANADA
基金
英国医学研究理事会;
关键词
D O I
10.1006/geno.1996.0499
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Asymmetric transport of mRNA within the cells is mediated by RNA-binding proteins that form, along with the mRNAs and perhaps other small RNAs, stable ribonucleoprotein complexes. However, the nature of the protein components of these complexes in vertebrates is still unknown. In Drosophila, genetic studies have identified a number of potential genes that are necessary for localization of mRNAs in oocytes; one of the most studied is the staufen gene. The staufen protein has been shown to bind to localized mRNAs in oocytes and to be expressed in somatic cells as well. To understand the mechanism of mRNA transport in mammals and characterize its components, we recently cloned and sequenced the human staufen homolog cDNA (HGMW-approved symbol STAU), In this paper, me show that the gene is unique in the human genome and report its chromosomal localization by fluorescence in situ hybridization. The human staufen gene maps to chromosome 20q13.1, a region that is associated with certain genetic diseases. (C) 1996 Academic Press, Inc.
引用
收藏
页码:527 / 529
页数:3
相关论文
共 18 条
[1]   MOLECULAR ANALYSIS OF CHROMOSOME 20Q DELETIONS ASSOCIATED WITH MYELOPROLIFERATIVE DISORDERS AND MYELODYSPLASTIC SYNDROMES [J].
ASIMAKOPOULOS, FA ;
WHITE, NJ ;
NACHEVA, E ;
GREEN, AR .
BLOOD, 1994, 84 (09) :3086-3094
[2]  
Beck C, 1994, Neurobiol Dis, V1, P95, DOI 10.1006/nbdi.1994.0012
[3]   CONSERVED STRUCTURES AND DIVERSITY OF FUNCTIONS OF RNA-BINDING PROTEINS [J].
BURD, CG ;
DREYFUSS, G .
SCIENCE, 1994, 265 (5172) :615-621
[4]   LOCALIZED RNAS AND THEIR FUNCTIONS [J].
DING, D ;
LIPSHITZ, HD .
BIOESSAYS, 1993, 15 (10) :651-658
[5]  
DROUIN R, 1988, CYTOBIOS, V56, P107
[6]   STAUFEN PROTEIN ASSOCIATES WITH THE 3'UTR OF BICOID MESSENGER-RNA TO FORM PARTICLES THAT MOVE IN A MICROTUBULE-DEPENDENT MANNER [J].
FERRANDON, D ;
ELPHICK, L ;
NUSSLEINVOLHARD, C ;
STJOHNSTON, D .
CELL, 1994, 79 (07) :1221-1232
[7]   A SIMPLE METHOD FOR SIMULTANEOUS R-BANDING OR G-BANDING AND FLUORESCENCE INSITU HYBRIDIZATION OF SMALL SINGLE-COPY GENES [J].
LEMIEUX, N ;
DUTRILLAUX, B ;
VIEGASPEQUIGNOT, E .
CYTOGENETICS AND CELL GENETICS, 1992, 59 (04) :311-312
[8]   CONFIRMATION OF LINKAGE OF BENIGN FAMILIAL NEONATAL CONVULSIONS TO D20S19 AND D20S20 [J].
MALAFOSSE, A ;
LEBOYER, M ;
DULAC, O ;
NAVELET, Y ;
PLOUIN, P ;
BECK, C ;
LAKLOU, H ;
MOUCHNINO, G ;
GRANDSCENE, P ;
VALLEE, L ;
GUILLOUDBATAILLE, M ;
SAMOLYK, D ;
BALDYMOULINIER, M ;
FEINGOLD, J ;
MALLET, J .
HUMAN GENETICS, 1992, 89 (01) :54-58
[9]   TUMOR PROGRESSION IN A GIANT-CELL TYPE MALIGNANT FIBROUS HISTIOCYTOMA OF BONE - CLINICAL, RADIOLOGIC, HISTOLOGIC, AND CYTOGENETIC EVIDENCE [J].
MOLENAAR, WM ;
VANDENBERG, E ;
VETH, RPH ;
DIJKHUIZEN, T ;
DEVRIES, EGE .
GENES CHROMOSOMES & CANCER, 1994, 10 (01) :66-70
[10]   LOCALIZATION OF A GENE FOR AUTOSOMAL-DOMINANT NOCTURNAL FRONTAL-LOBE EPILEPSY TO CHROMOSOME 20Q13.2 [J].
PHILLIPS, HA ;
SCHEFFER, IE ;
BERKOVIC, SF ;
HOLLWAY, GE ;
SUTHERLAND, GR ;
MULLEY, JC .
NATURE GENETICS, 1995, 10 (01) :117-118