Possible association between Cys311Ser polymorphism of paraoxonase 2 gene and late-onset Alzheimer's disease in Chinese

被引：32

作者：

Shi, JJ

Zhang, SZ ^{[1
]}

Tang, MN

Liu, XH

Li, T

Han, HY

Wang, YC

Guo, YB

Zhao, JH

Li, H

Ma, C

机构：

[1] W China Hosp, Dept Med Genet, Key Lab Biotherapy Human Dis, Chengdu 610041, Peoples R China

[2] Sichuan Univ, Minist Educ, Div Human Morbid Genomics, Chengdu 610041, Peoples R China

[3] Sichuan Univ, Dept Adv Math, Chengdu 610041, Peoples R China

[4] Int Ctr Hlth & Soc, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England

[5] Inst Psychiat, Dept Psychol Med, London SE5 8AF, England

[6] Sichuan Univ, Inst Mental Hlth, W China Hosp, Chengdu 610041, Peoples R China

[7] Guangzhou Psychiat Hosp, Guangzhou 510370, Peoples R China

来源：

MOLECULAR BRAIN RESEARCH | 2004年 / 120卷 / 02期

基金：

中国国家自然科学基金;

关键词：

paraoxonase; 2; apolipoprotein E; Alzheimer's disease; polymorphism;

D O I：

10.1016/j.molbrainres.2003.10.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The common polymorphism at codon 311 (C311S) of paraoxonase 2 gene (PON2) was investigated in 165 patients with sporadic late-onset Alzheimer's disease (LOAD) and 174 controls in Chinese. The PON2*C allele frequency was significantly increased in the patients as compared with controls. However, no significant difference was observed after stratification of apolipoprotein E (ApoE) epsilon4 allele. These results suggested that the PON2 polymorphism might be a risk factor for LOAD independent of ApoE epsilon4 status in Chinese. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：201 / 204

页数：4

共 13 条

[1] OXIDATIVE STRESS AND ALZHEIMERS-DISEASE [J].