An efficient synthesis of julibrosides related to neosaponin

被引：9

作者：

Du, YG ^{[1
]}

Zhang, MM ^{[1
]}

Kong, FZ ^{[1
]}

机构：

[1] Chinese Acad Sci, Ecoenvironm Sci Res Ctr, Beijing 100085, Peoples R China

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2001年 / 18期

关键词：

D O I：

10.1039/b009955o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical method is developed for the synthesis of neosaponin cholest-5(6)-en-3 beta -yl beta -D-glucopyranosyl-(1-->3)-[alpha -L-arabinofuranosyl-(1-->4)]-alpha -L-rhamnopyranosyl-(1-->2)-beta -D-glucopyranoside. This julibroside mimic shows cytotoxic activity towards P388 (mouse leukaemia) with GI(50) = 22.5 mug mL(-1).

引用

页码：2289 / 2293

页数：5

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