Cytotoxic T-Lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer

被引：268

作者：

Blansfield, JA ^{[1
]}

Beck, KE ^{[1
]}

Tran, K ^{[1
]}

Yang, DC ^{[1
]}

Hughes, MS ^{[1
]}

Kammula, US ^{[1
]}

Royal, RE ^{[1
]}

Topalian, SL ^{[1
]}

Haworth, LR ^{[1
]}

Levy, C ^{[1
]}

Rosenberg, SA ^{[1
]}

Sherry, RM ^{[1
]}

机构：

[1] NCI, Surg Branch, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF IMMUNOTHERAPY | 2005年 / 28卷 / 06期

关键词：

anti-CTLA-4; antibody; autoimmunity; autoimmune hypophysitis; melanoma; renal cell cancer; immunotherapy;

D O I：

10.1097/01.cji.0000178913.41256.06

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is an immunoregulatory molecule expressed by activated T cells and resting CD4(+)CD25(+) T cells. In patients with advanced melanoma, Our Group reported that administration of anti-CTLA-4 antibody mediated objective cancer regression in 13% of patients. This study also established that the blockade of CTLA-4 was associated with grade III/IV autoimmune manifestations that included dermatitis, enterocolitis, hepatitis, uveitis, and a single case of hypophysitis. Since this initial report, 7 additional patients with anti-CTLA-4 antibody-induced autoimmune hypophysitis have been accumulated. The characteristics, clinical course, laboratory values, radiographic findings, and treatment of these 8 patients are the focus of this report.

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页码：593 / 598

页数：6

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