Role of (p)ppGpp in Biofilm Formation by Enterococcus faecalis

被引：55

作者：

de Paz, Luis E. Chavez ^{[1
,2
]}

Lemos, Jose A. ^{[3
,4
]}

Wickstrom, Claes ^{[1
]}

Sedgley, Christine M. ^{[5
]}

机构：

[1] Malmo Univ, Fac Odontol, Dept Oral Biol, Malmo, Sweden

[2] Univ Connecticut, Ctr Hlth, Sch Dent Med, Div Endodontol, Farmington, CT USA

[3] Univ Rochester, Med Ctr, Ctr Oral Biol, Rochester, NY 14642 USA

[4] Univ Rochester, Med Ctr, Dept Microbiol, Rochester, NY 14642 USA

[5] Oregon Hlth & Sci Univ, Sch Dent, Dept Endodontol, Portland, OR 97201 USA

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2012年 / 78卷 / 05期

关键词：

SURVIVAL; TEETH;

D O I：

10.1128/AEM.07036-11

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Enterococcus faecalis strain OG1RF and its (p)ppGpp-deficient Delta relA, Delta relQ, and Delta relA Delta relQ mutants were grown in biofilms and evaluated for growth profiles, biofilm morphology, cell viability, and proteolytic activity. E. faecalis lacking (p)ppGpp had a diminished capacity to sustain biofilm formation over an extended period of time and expressed abundant proteolytic activity.

引用

页码：1627 / 1630

页数：4

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