Cytotoxic and mutagenic response of mismatch repair-defective human cancer cells exposed to a food-associated heterocyclic amine

被引：20

作者：

Glaab, WE ^{[1
]}

Skopek, TR ^{[1
]}

机构：

[1] Merck Res Labs, Dept Genet & Cellular Toxicol, W Point, PA 19486 USA

来源：

CARCINOGENESIS | 1999年 / 20卷 / 03期

关键词：

D O I：

10.1093/carcin/20.3.391

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The cytotoxic and mutagenic effects of 2-amino-1-methyl-6-phenylimidazo-[4,5-b]-pyridine (PhIP), a food-associated heterocyclic amine, were measured in three human cancer cell lines possessing different mismatch repair (MMR) defects and in matched cell lines corrected for the MMR deficiencies by specific chromosome transfer. Cells deficient in MMR were more resistant to PhIP-induced cytotoxicity and displayed similar to 3-fold more induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus, These results suggest that defects in MMR carried by patients with hereditary nonpolyposis colorectal cancer syndrome may result in enhanced sensitivity to certain dietary and environmental carcinogens such as PhIP.

引用

页码：391 / 394

页数：4

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