A new SHV-derived extended-spectrum β-lactamase (SHV-24) that hydrolyzes ceftazidime through a single-amino-acid substitution (D179G) in the Ω-loop

被引：22

作者：

Kurokawa, H ^{[1
]}

Yagi, T ^{[1
]}

Shibata, N ^{[1
]}

Shibayama, K ^{[1
]}

Kamachi, K ^{[1
]}

Arakawa, Y ^{[1
]}

机构：

[1] Natl Inst Infect Dis, Dept Bacterial & Blood Prod, Tokyo 2080011, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 06期

关键词：

D O I：

10.1128/AAC.44.6.1725-1727.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A new SHV-derived extended-spectrum p-lactamase (SHV-24) conferring high-level resistance to ceftazidime but not cefotaxime and cefazolin was identified in Japan. This enzyme was encoded by a transferable 150-kb plasmid from an Escherichia coli clinical isolate. The pI and K-m for CAZ of this enzyme were 7.5 and 30 mu M, respectively. SHV-24 was found to have a D179G substitution in the Omega-loop of the enzyme.

引用

页码：1725 / 1727

页数：3

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