In and out of the postsynaptic region: signalling proteins on the move

被引：26

作者：

Meyer, T

Shen, K

机构：

[1] Stanford Univ, Sch Med, Dept Mol Pharmacol, Stanford, CA 94305 USA

[2] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

来源：

TRENDS IN CELL BIOLOGY | 2000年 / 10卷 / 06期

关键词：

D O I：

10.1016/S0962-8924(00)01764-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reversible translocation of signalling proteins to and from their sites of action has emerged as an important theme in Signal transduction. The recent findings of the stimulus-induced translocation of Ca2+-calmodulin dependent protein kinase II (CaMKII) and the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor to and from the postsynaptic region are model cases for understanding how the dynamic localization of signalling protein is used to regulate signal transduction.

引用

收藏

页码：238 / 244

页数：7

相关论文

共 57 条

[1] Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B [J].

Anderson, KE ;

Coadwell, J ;

Stephens, LR ;

Hawkins, PT .

CURRENT BIOLOGY, 1998, 8 (12) :684-691

[2] Role of translocation in the activation and function of protein kinase B [J].

Andjelkovic, M ;

Alessi, DR ;

Meier, R ;

Fernandez, A ;

Lamb, NJC ;

Frech, M ;

Cron, P ;

Cohen, P ;

Lucocq, JM ;

Hemmings, BA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (50) :31515-31524

[3] Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation [J].

Barria, A ;

Muller, D ;

Derkach, V ;

Griffith, LC ;

Soderling, TR .

SCIENCE, 1997, 276 (5321) :2042-2045

[4] IMPAIRMENT OF SPATIAL BUT NOT CONTEXTUAL MEMORY IN CAMKII MUTANT MICE WITH A SELECTIVE LOSS OF HIPPOCAMPAL LTP IN THE RANGE OF THE THETA-FREQUENCY [J].

BEACH, ME ;

HAWKINS, RD ;

OSMAN, M ;

KANDEL, ER ;

MAYFORD, M .

CELL, 1995, 81 (06) :905-915

[5]

BENNETT MK, 1983, J BIOL CHEM, V258, P2735

[6]

BERRIDGE MJ, 1990, J BIOL CHEM, V265, P9583

[7] Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP [J].

Blitzer, RD ;

Conner, JH ;

Brown, GP ;

Wong, T ;

Shenolikar, S ;

Iyengar, R ;

Landau, EM .

SCIENCE, 1998, 280 (5371) :1940-1943

[8] CaMKII-dependent phosphorylation of NR2A and NR2B is decreased in animals characterized by hippocampal damage and impaired LTP [J].

Caputi, A ;

Gardoni, F ;

Cimino, M ;

Pastorino, L ;

Cattabeni, F ;

Di Luca, M .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1999, 11 (01) :141-148

[9] Abnormal hippocampal spatial representations in αCaMKIIT286A and CREBαΔ- mice [J].

Cho, YH ;

Giese, KP ;

Tanila, H ;

Silva, AJ ;

Eichenbaum, H .

SCIENCE, 1998, 279 (5352) :867-869

[10] GLUTAMATE INDUCES CALCIUM WAVES IN CULTURED ASTROCYTES - LONG-RANGE GLIAL SIGNALING [J].

CORNELLBELL, AH ;

FINKBEINER, SM ;

COOPER, MS ;

SMITH, SJ .

SCIENCE, 1990, 247 (4941) :470-473

← 1 2 3 4 5 6 →