The intestinal epithelial cell: Immunological aspects

被引:56
作者
Christ, AD [1 ]
Blumberg, RS [1 ]
机构
[1] HARVARD UNIV, BRIGHAM & WOMENS HOSP, SCH MED, DIV GASTROENTEROL, BOSTON, MA 02115 USA
来源
SPRINGER SEMINARS IN IMMUNOPATHOLOGY | 1997年 / 18卷 / 04期
关键词
D O I
10.1007/BF00824052
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
IECs likely play an important role in immunological defense mechanism. Apart from being a passive barrier against luminal bacteria, IECs secrete protective and microbiocidal products such as ITF, complement components and cryptdins into the lumen. Moreover, IECs produce secretory component that is essential for the transport of IgA from the lamina propria into the lumen. IECs also have regulatory functions. They express adhesion molecules important in the homing of T cells and other leukocytes, and likely modulate T cell functions in a paracrine way. Furthermore, IECs secrete cytokines, either constitutively or after bacterial challenge, and they express cytokine receptors. Lastly, IECs may play an important role as non-professional antigen-presenting cells by expressing classical MHC class I and class II and non-classical MHC class I molecules on the cell surface. This aspect is particularly intriguing in that IECs also express a FcR that may have a function in luminal antigen sampling.
引用
收藏
页码:449 / 461
页数:13
相关论文
共 106 条
[1]  
ALLEN A, 1982, ADV EXP MED BIOL, V144, P115
[2]  
ANDOH A, 1993, J IMMUNOL, V151, P4239
[3]  
ANZANO MA, 1989, CANCER RES, V49, P2898
[4]   A 2ND LINEAGE OF MAMMALIAN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I GENES [J].
BAHRAM, S ;
BRESNAHAN, M ;
GERAGHTY, DE ;
SPIES, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (14) :6259-6263
[5]   COMPOSITION OF TCR-CD3 COMPLEX IN HUMAN INTESTINAL INTRAEPITHELIAL LYMPHOCYTES - LACK OF FC-EPSILON-RI-GAMMA CHAIN [J].
BALK, SP ;
POLISCHUK, JE ;
PROBERT, C ;
STEVENS, C ;
EBERT, E ;
SHE, J ;
TERHORST, C ;
BLUMBERG, RS .
INTERNATIONAL IMMUNOLOGY, 1995, 7 (08) :1237-1241
[6]   BETA(2)-MICROGLOBULIN-INDEPENDENT MHC CLASS IB MOLECULE EXPRESSED BY HUMAN INTESTINAL EPITHELIUM [J].
BALK, SP ;
BURKE, S ;
POLISCHUK, JE ;
FRANTZ, ME ;
YANG, L ;
PORCELLI, S ;
COLGAN, SP ;
BLUMBERG, RS .
SCIENCE, 1994, 265 (5169) :259-262
[7]   OLIGOCLONAL EXPANSION AND CD1 RECOGNITION BY HUMAN INTESTINAL INTRAEPITHELIAL LYMPHOCYTES [J].
BALK, SP ;
EBERT, EC ;
BLUMENTHAL, RL ;
MCDERMOTT, FV ;
WUCHERPFENNIG, KW ;
LANDAU, SB ;
BLUMBERG, RS .
SCIENCE, 1991, 253 (5026) :1411-1415
[8]  
Barrera S, 1996, J CELL PHYSIOL, V166, P130, DOI 10.1002/(SICI)1097-4652(199601)166:1<130::AID-JCP15>3.0.CO
[9]  
2-J
[10]  
BEAGLEY KW, 1995, J IMMUNOL, V154, P5611