Sodium tanshinone IIA sulfonate mediates electron transfer reaction in rat heart mitochondria

被引：61

作者：

Zhou, GY

Jiang, W

Zhao, Y

Ma, GG

Xin, WJ

Yin, JJ

Zhao, BL ^{[1
]}

机构：

[1] Acad Sinica, Inst Biophys, Dept Mol & Cell Biophys, Lab Visual Informat Proc, Beijing 100101, Peoples R China

[2] Natl Inst Pharmaceut Res & Dev, Beijing 102206, Peoples R China

[3] US FDA, CFSAN, Instrumentat & Biophys Branch, College Pk, MD 20740 USA

来源：

BIOCHEMICAL PHARMACOLOGY | 2003年 / 65卷 / 01期

基金：

中国国家自然科学基金;

关键词：

sodium tanshinone IIA sulfonate (STS); mitochondria; respiratory chain; free radicals; antioxidant; electron spin resonance (ESR);

D O I：

10.1016/S0006-2952(02)01447-8

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

In this paper, an electron transfer reaction mediated by sodium tanshinone IIA sulfonate (STS) was studied in rat heart mitochondria. It was found that STS could stimulate mitochondrial NADH oxidation dose-dependently and partly restore NADH oxidation in the presence of respiratory inhibitor (rotenone or antimycin A or KCN). It was likely that STS could accept electrons from complex I similar to ferricyanide and could be converted to its semiquinone form that could then reduce oxygen molecule. The data also showed that cytochrome c (Cyt c) could be reduced by STS in the presence of KCN, or STS could transfer the electron to oxygen directly. Free radicals were involved in the process. The results suggest that STS may protect ischemia-reperfusion injury through an electron transfer reaction in mitochondria against forming reactive oxygen radicals. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：51 / 57

页数：7

共 24 条

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