Further immunohistochemical evidence for impaired NO signaling in the hypothalamus of depressed patients

被引：42

作者：

Bernstein, HG

Heinemann, A

Krell, D

Mawrin, C

Bielau, H

Danos, P

Diekmann, S

Keilhoff, G

Bogerts, B

Baumann, B

机构：

[1] Univ Magdeburg, Dept Psychiat, D-39120 Magdeburg, Germany

[2] Univ Magdeburg, Dept Neuropathol, D-39120 Magdeburg, Germany

[3] Univ Magdeburg, Inst Med Neurobiol, D-39120 Magdeburg, Germany

来源：

CELL SIGNALING, TRANSCRIPTION, AND TRANSLATION AS THERAPEUTIC TARGETS | 2002年 / 973卷

关键词：

nitric oxide synthase; neurophysin; immunohistochemistry; suprachiasmatic nucleus; depression;

D O I：

10.1111/j.1749-6632.2002.tb04613.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cellular expression of nitric oxide synthase (NOS) was studied in neurons of the Nuc. suprachiasmaticus (SCN) of depressed patients and matched controls. The number of NOS-immunoreactive SCN neurons was significantly reduced in depression. We conclude that affective disorders are accompanied by impaired hypothalamic NO signaling.

引用

页码：91 / 93

页数：3

共 5 条

[1] Low and infrequent expression of nitric oxide synthase/NADPH-diaphorase in neurons of the human supraoptic nucleus: a histochemical study [J].