Act1-ivating IL-17 inflammation

被引：26

作者：

Hunter, Christopher A. ^{[1
]}

机构：

[1] Univ Penn, Sch Vet Med, Philadelphia, PA 19104 USA

来源：

NATURE IMMUNOLOGY | 2007年 / 8卷 / 03期

关键词：

D O I：

10.1038/ni0307-232

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The signaling adaptor Act1 is now shown in vivo to be essential for interleukin 17-mediated inflammation in the brain during experimental autoimmune encephalomyelitis and in gut epithelial cells during induced colitis.

引用

页码：232 / 234

页数：4

共 12 条

[1]

Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor [J].

Chang, Seon Hee ;

Park, Heon ;

Dong, Chen .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (47) :35603-35607

[2]

New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions [J].

Hunter, CA .

NATURE REVIEWS IMMUNOLOGY, 2005, 5 (07) :521-531

[3]

IL-23 promotes tumour incidence and growth [J].

Langowski, John L. ;

Zhang, Xueqing ;

Wu, Lingling ;

Mattson, Jeanine D. ;

Chen, Taiying ;

Smith, Kathy ;

Basham, Beth ;

McClanahan, Terrill ;

Kastelein, Robert A. ;

Oft, Martin .

NATURE, 2006, 442 (7101) :461-465

[4]

IL-12 and IL-23: master regulators of innate and adaptive immunity [J].

Langrish, CL ;

McKenzie, BS ;

Wilson, NJ ;

Malefyt, RD ;

Kastelein, RA ;

Cua, DJ .

IMMUNOLOGICAL REVIEWS, 2004, 202 :96-105

[5]

CIKS, a connection to IκB kinase and stress-activated protein kinase [J].

Leonardi, A ;

Chariot, A ;

Claudio, E ;

Cunningham, K ;

Siebenlist, U .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (19) :10494-10499

[6]

Act1, an NF-κB-activating protein [J].

Li, XX ;

Commane, M ;

Nie, HQ ;

Hua, XX ;

Chatterjee-Kishore, M ;

Wald, D ;

Haag, M ;

Stark, GR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (19) :10489-10493

[7]

The STIR-domain superfamily in signal transduction, development and immunity [J].

Novatchkova, M ;

Leibbrandt, A ;

Werzowa, J ;

Neubüser, A ;

Eisenhaber, F .

TRENDS IN BIOCHEMICAL SCIENCES, 2003, 28 (05) :226-229

[8]

Act1, a negative regulator in CD40- and BAFF-mediated B cell survival [J].

Qian, YC ;

Qin, JZ ;

Cui, G ;

Naramura, M ;

Snow, EC ;

Ware, CF ;

Fairchild, RL ;

Omori, SA ;

Rickert, RC ;

Scott, M ;

Kotzin, BL ;

Li, XX .

IMMUNITY, 2004, 21 (04) :575-587

[9]

Role of NFκB activator Act1 in CD40-mediated signaling in epithelial cells [J].

Qian, YC ;

Zhao, ZD ;

Jiang, ZF ;

Li, XX .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (14) :9386-9391

[10]

The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease [J].

Qian, Youcun ;

Liu, Caini ;

Hartupee, Justin ;

Altuntas, Cengiz Zubeyir ;

Gulen, Muhammet Fatih ;

Jane-wit, Daniel ;

Xiao, Jianhua ;

Lu, Yi ;

Giltiay, Natalia ;

Liu, Jinbo ;

Kordula, Tomasz ;

Zhang, Qi-Wei ;

Vallance, Bruce ;

Swaidani, Shadi ;

Aronica, Mark ;

Tuohy, Vincent K. ;

Hamilton, Thomas ;

Li, Xiaoxia .

NATURE IMMUNOLOGY, 2007, 8 (03) :247-256

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