Strain relaxation of fibroblasts in the marginal periodontium is the common trigger for alveolar bone resorption: A novel hypothesis

被引:22
作者
Binderman, I [1 ]
Bahar, H
Yaffe, A
机构
[1] Tel Aviv Univ, Dept Oral Biol, Maurice & Gabriela Goldschleger Sch Dent Med, IL-69978 Tel Aviv, Israel
[2] Hebrew Univ Jerusalem, Fac Dent, Dept Prosthodont, Jerusalem, Israel
关键词
D O I
10.1902/jop.2002.73.10.1210
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
In summary, the present commentary proposes a hypothesis that alveolar bone remodeling and bone loss in periodontitis, periodontal surgery, and in orthodontic tooth movement is triggered by a common "strain relaxation" signaling pathway of gingival and periodontal fibroblasts. The abrupt splitting, degradation, or relaxation of collagen fibers in the marginal periodontium produces a "strain relaxation" signal in the local fibroblasts which reside on these fibers, activating an ECM-integrin-cytoskeleton pathway. A cascade of cellular reactions which lead to osteoclastic bone resorption starting on the inner aspect (periodontal) of the alveolar bone then persists. A novel therapeutic approach is suggested here by using locally delivered drugs intervening in the cell contractile apparatus.
引用
收藏
页码:1210 / 1215
页数:6
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