MMP9 potentiates pulmonary metastasis formation

被引：159

作者：

van Kempen, LCL

Coussens, LM

机构：

[1] Univ Calif San Francisco, Inst Canc Res, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Ctr Comprehens Canc, San Francisco, CA 94143 USA

来源：

CANCER CELL | 2002年 / 2卷 / 04期

关键词：

D O I：

10.1016/S1535-6108(02)00157-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor cell dissemination to distant organ sites is a complex process involving multiple cell types, soluble growth factors, adhesion receptors, and tissue remodeling. A new study in this issue of Cancer Cell shows that MMP9-expressing tumor-associated macrophages play a key role in prepping premetastatic sites for eventual malignant cell growth in a manner dependent upon vascular endothelial growth factor receptor-1 (VEGFR-1).

引用

收藏

页码：251 / 252

页数：2

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