Cabergoline plasma concentration is increased during concomitant treatment with itraconazole

被引：9

作者：

Christensen, J

Dupont, E

Ostergaard, K

机构：

[1] Univ Aarhus, Dept Pharmacol, Ctr Clin Pharmacol, DK-8000 Aarhus C, Denmark

[2] Aarhus Univ Hosp, Dept Neurol, DK-8000 Aarhus, Denmark

来源：

MOVEMENT DISORDERS | 2002年 / 17卷 / 06期

关键词：

Parkinson's disease; cabergoline; itraconazole; cytochrome P-450; drug interactions;

D O I：

10.1002/mds.10250

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report on 2 patients with idiopathic Parkinson's disease who experienced marked improvement in symptoms following, the addition of itraconazole to current cabergoline treatment. Plasma levels of cabergoline were analyzed in one of the patients and increased to approximately 300% during treatment with itraconazole, which paralleled major clinical improvement. (C) 2002 Movement Disorder Society.

引用

页码：1360 / 1362

页数：3

共 20 条

[1]

BENNETT JE, 2001, PHARMACOL BASIS, P1295

[2]

Pharmacology of itraconazole [J].