Human papillomavirus type-distribution in cervical cancer in China: the importance of HPV 16 and 18

被引：108

作者：

Chen, Wen ^{[1
,2
]}

Zhang, Xun ^{[1
]}

Molijn, Anco ^{[3
]}

Jenkins, David ^{[4
]}

Shi, Ju-Fang ^{[1
]}

Quint, Wim ^{[3
]}

Schmidt, Johannes E. ^{[5
]}

Wang, Ping ^{[6
]}

Liu, Yu-Ling ^{[7
]}

Li, Lian-Kun ^{[8
]}

Shi, Hong ^{[9
]}

Liu, Ji-Hong ^{[10
]}

Xie, Xing ^{[11
]}

Niyazi, Mayinuer ^{[12
]}

Yang, Pei ^{[13
]}

Wei, Li-Hui ^{[14
]}

Li, Long-Yu ^{[15
]}

Li, Jie ^{[16
]}

Liu, Jin-Feng ^{[17
]}

Zhou, Qi ^{[18
]}

Hong, Ying ^{[19
]}

Li, Li ^{[20
]}

Li, Qing ^{[21
]}

Zhou, Hong-Lin ^{[22
]}

Bian, Mei-Lu ^{[23
]}

Chen, Jing ^{[24
]}

Qiao, You-Lin ^{[1
]}

Smith, Jennifer S. ^{[25
]}

机构：

[1] Chinese Acad Med Sci, Inst Canc, Beijing 100021, Peoples R China

[2] Peking Union Med Coll, Sch Basic Med, Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100021, Peoples R China

[3] DDL Diagnost Lab, Voorburg, Netherlands

[4] Univ Nottingham, Nottingham NG7 2RD, England

[5] GlaxoSmithKline Biol, Rixensart, Belgium

[6] Shaanxi Canc Hosp, Xian, Peoples R China

[7] Zhengzhou Univ, Affiliated Hosp 2, Zhengzhou, Peoples R China

[8] Liaoning Canc Hosp, Shenyang, Peoples R China

[9] Dalian Med Univ, Affiliated Hosp 1, Dalian, Peoples R China

[10] Sun Yat Sen Univ, Canc Hosp, Guangzhou 510275, Guangdong, Peoples R China

[11] Zhejiang Med Univ, Womens Hosp, Hangzhou, Zhejiang, Peoples R China

[12] Xinjiang Peoples Hosp, Urumqi, Peoples R China

[13] Sichuan Univ, Affiliated Hosp 2, Chengdu 610064, Peoples R China

[14] Beijing Univ, Peoples Hosp, Beijing 100871, Peoples R China

[15] Jiangxi Women & Childrens Hosp, Nanchang, Peoples R China

[16] Hunan Peoples Hosp, Changsha, Hunan, Peoples R China

[17] Gansu Women & Childrens Hosp, Lanzhou, Peoples R China

[18] Chongqing Canc Hosp, Chongqing, Peoples R China

[19] Gulou Hosp, Nanjing, Peoples R China

[20] Guangxi Canc Hosp, Nanning, Peoples R China

[21] Shenzhen Women & Childrens Hosp, Shenzhen, Peoples R China

[22] Kunming Med Coll, Affiliated Hosp 2, Kunming, Peoples R China

[23] China Japan Friendship Hosp, Beijing, Peoples R China

[24] GlaxoSmithKline Biol, Singapore, Singapore

[25] Univ N Carolina, Chapel Hill, NC USA

来源：

CANCER CAUSES & CONTROL | 2009年 / 20卷 / 09期

关键词：

Human papillomavirus; Cervical cancer; High-grade squamous intraepithelial lesions; Epidemiology; China; RISK-FACTORS; WOMEN; INFECTION; CARCINOMA; NEOPLASIA; PROVINCE;

D O I：

10.1007/s10552-009-9422-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prophylactic vaccination against HPV 16 and 18 has the potential for effective prevention of high-grade precancer (cervical intraepithelial neoplasia [CIN)] 2/3) and ICC caused by these viruses (globally 50 and 70%, respectively) when employed in women prior to starting sexual activity. To provide data for decisions on HPV vaccination in China, we determined HPV type-distribution in ICC and CIN 2/3 from women of different regions within China. A multicenter study was conducted by randomized sampling of paraffin blocks of 664 ICC (630 squamous cell carcinoma [SCC]; 34 adenocarcinoma [ADC]), 569 CIN 2/3 cases from seven regions of China. Histological diagnosis was confirmed in 1,233 cases by consensus review. HPV DNA was detected using the SPF10 LiPA25 version 1 assay. HPV prevalence was 97.6% in SCC, 85.3% in adenocarcinoma, and 98.9% in CIN 2/3. HPV 16 (76.7%) and HPV 18 (7.8%) were the most common, together accounting for 84.5% of SCC, followed by HPV 31 (3.2%), HPV 52 (2.2%), and HPV 58 (2.2%). HPV positivity in SCC did not differ notably by region. However, SCC cases from women <= 34 years had higher HPV 16 positivity than women over 50 years, among whom HPV 52, 58, and 39 were more common. HPV 16 and 18 were under-represented, whereas HPV 31, 52, and 58 were over-represented in CIN2/3 compared to SCC. The potential impact of vaccines against oncogenic HPV types 16 and 18 is estimated to be high (84.5%) against total SCC. These data are critical for China's future evaluation of the cost-effectiveness of current cervical cancer vaccines and of HPV-based screening guidelines.

引用

页码：1705 / 1713

页数：9