Phytochemical compounds involved in the anti-inflammatory effect of propolis extract

被引：182

作者：

Borrelli, F

Maffia, P

Pinto, L

Ianaro, A

Russo, A

Capasso, F

Ialenti, A

机构：

[1] Univ Naples Federico II, Dept Expt Pharmacol, I-80131 Naples, Italy

[2] Univ Catania, Dept Biochem Med Chem & Mol Biol, Catania, Italy

来源：

FITOTERAPIA | 2002年 / 73卷

关键词：

propolis; CAPE; galangin; inflammation;

D O I：

10.1016/S0367-326X(02)00191-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two ethanolic propolis extracts (EPE) with and without the caffeic acid phenethyl ester (CAPE), CAPE and galangin (major components of propolis) were investigated for anti-inflammatory activity in rats using carrageenin foot oedema, carrageenin pleurisy and adjuvant arthritis. In our experiments, EPE with CAPE and CAPE alone significantly inhibited carrageenin oedema, carrageenin pleurisy and adjuvant arthritis. In contrast EPE without CAPE and galangin did not exhibit anti-inflammatory effects in acute and chronic inflammation. These results suggest that the anti-inflammatory activity of propolis is due to CAPE. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：S53 / S63

页数：11

共 34 条

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