A cancer therapy resistant to resistance

被引：293

作者：

Kerbel, RS

机构：

[1] the University of Toronto,

[2] and in the Cancer Research Program,undefined

[3] Sunnybrook Health Science Centre,undefined

来源：

NATURE | 1997年 / 390卷 / 6658期

关键词：

D O I：

10.1038/36978

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The relentless growth of tumours depends on a good blood supply, and thus on subverting host mechanisms for making blood vessels. Attack on that process provides a promising route for treating cancer, but one that may take some years to reach clinical fruition.

引用

页码：335 / 336

页数：2

共 21 条

[1] VASCULAR ENDOTHELIAL GROWTH-FACTOR ACTS AS A SURVIVAL FACTOR FOR NEWLY FORMED RETINAL-VESSELS AND HAS IMPLICATIONS FOR RETINOPATHY OF PREMATURITY
ALON, T
HEMO, I
ITIN, A
PEER, J
STONE, J
KESHET, E
[J]. NATURE MEDICINE, 1995, 1 (10) : 1024 - 1028
[2] Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal
Benjamin, LE
Keshet, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (16) : 8761 - 8766
[3] Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
Boehm, T
Folkman, J
Browder, T
OReilly, MS
[J]. NATURE, 1997, 390 (6658) : 404 - 407
[4] How tumors become angiogenic
Bouck, N
Stellmach, V
Hsu, SC
[J]. ADVANCES IN CANCER RESEARCH, VOL 69, 1996, 69 : 135 - 174
[5] REDUCTION BY GRANULOCYTE COLONY-STIMULATING FACTOR OF FEVER AND NEUTROPENIA INDUCED BY CHEMOTHERAPY IN PATIENTS WITH SMALL-CELL LUNG-CANCER
CRAWFORD, J
OZER, H
STOLLER, R
JOHNSON, D
LYMAN, G
TABBARA, I
KRIS, M
GROUS, J
PICOZZI, V
RAUSCH, G
SMITH, R
GRADISHAR, W
YAHANDA, A
VINCENT, M
STEWART, M
GLASPY, J
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (03) : 164 - 170
[6] FOLKMAN J, 1971, NEW ENGL J MED, V285, P1182
[7] Tumor angiogenesis and tissue factor
Folkman, J
[J]. NATURE MEDICINE, 1996, 2 (02) : 167 - 168
[8] Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
Hanahan, D
Folkman, J
[J]. CELL, 1996, 86 (03) : 353 - 364
[9] DELIVERY OF NOVEL THERAPEUTIC AGENTS IN TUMORS - PHYSIOLOGICAL BARRIERS AND STRATEGIES
JAIN, RK
[J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (08): : 570 - 576
[10] INHIBITION OF TUMOR ANGIOGENESIS AS A STRATEGY TO CIRCUMVENT ACQUIRED-RESISTANCE TO ANTICANCER THERAPEUTIC AGENTS
KERBEL, RS
[J]. BIOESSAYS, 1991, 13 (01) : 31 - 36

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