Epigenetic consequences of nucleosome dynamics

被引：100

作者：

Ahmad, K ^{[1
]}

Henikoff, S ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

来源：

CELL | 2002年 / 111卷 / 03期

关键词：

D O I：

10.1016/S0092-8674(02)01081-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Current models for epigenetic gene silencing envision a static relationship between histone modifications and transcription. However, evidence for nucleosome mobility and replacement favors a dynamic model that may explain phenomena ranging from variegation to the neural restriction of Rett syndrome.

引用

页码：281 / 284

页数：4

共 18 条

[1] The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly
Ahmad, K
Henikoff, S
[J]. MOLECULAR CELL, 2002, 9 (06) : 1191 - 1200
[2] Modulation of a transcription factor counteracts heterochromatic gene silencing in Drosophila
Ahmad, K
Henikoff, S
[J]. CELL, 2001, 104 (06) : 839 - 847
[3] Histone modification governs the cell cycle regulation of a replication-independent chromatin assembly pathway in Saccharomyces cerevisiae
Altheim, BA
Schultz, MC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (04) : 1345 - 1350
[4] Histone methylation: Dynamic or static?
Bannister, AJ
Schneider, R
Kouzarides, T
[J]. CELL, 2002, 109 (07) : 801 - 806
[5] DNA METHYLATION - EVOLUTION OF A BACTERIAL IMMUNE FUNCTION INTO A REGULATOR OF GENE-EXPRESSION AND GENOME STRUCTURE IN HIGHER EUKARYOTES
BESTOR, TH
[J]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1990, 326 (1235) : 179 - 187
[6] Unravelling heterochromatin: competition between positive and negative factors regulates accessibility
Dillon, N
Festenstein, R
[J]. TRENDS IN GENETICS, 2002, 18 (05) : 252 - 258
[7] Blocking transcription through a nucleosome with synthetic DNA ligands
Gottesfeld, JM
Belitsky, JM
Melander, C
Dervan, PB
Luger, K
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2002, 321 (02) : 249 - 263
[8] Gene silencing quantitatively controls the function of a developmental trans-activator
Hutchins, AS
Mullen, AC
Lee, HW
Sykes, KJ
High, FA
Hendrich, BD
Bird, AP
Reiner, SL
[J]. MOLECULAR CELL, 2002, 10 (01) : 81 - 91
[9] Interplay between two epigenetic marks: DNA methylation and histone H3 lysine 9 methylation
Johnson, LM
Cao, XF
Jacobsen, SE
[J]. CURRENT BIOLOGY, 2002, 12 (16) : 1360 - 1367
[10] Kelly WG, 2002, DEVELOPMENT, V129, P479

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