Investigation into the acidification process of zafirluskast nitroacid leads to a surprising improvement in product quality

被引：7

作者：

Ancell, CL ^{[1
]}

Derrick, I ^{[1
]}

Moseley, JD ^{[1
]}

Stott, JA ^{[1
]}

机构：

[1] AstraZeneca, Proc Res & Dev, Bristol BS10 7ZE, Avon, England

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2004年 / 8卷 / 05期

关键词：

D O I：

10.1021/op049911+

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An investigation into the acidification step of the zafirlukast nitroacid process was conducted by varying a range of parameters, including acid molarity, addition time, final pH, and temperature. A significant and unexpected improvement in product quality was achieved by using dilute rather than concentrated acid, independent of the final pH, and without a reduction in yield. The change to the dilute-acid process could be accommodated within the constraints of the existing registered process.

引用

页码：808 / 813

页数：6

共 3 条

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