Evidence for presence of Ig64 anti-immunoglobulin autoantibodies in all human beings

被引：24

作者：

Hennig, C ^{[1
]}

Rink, L ^{[1
]}

Kirchner, H ^{[1
]}

机构：

[1] Univ Lubeck, Sch Med, Inst Immunol & Transfus Med, D-23562 Lubeck, Germany

来源：

LANCET | 2000年 / 355卷 / 9215期

关键词：

D O I：

10.1016/S0140-6736(00)02223-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

IgG4 anti-IgG autoantibodies were found to be present in all serum samples from a group of healthy people; IgG4 anti-IgA and anti-IgE were present in only 13 of 218 (6%) and 8 of 218 (3.5%) samples, respectively. These antibodies also showed affinities towards animal immunoglobulins. We suggest that IgG4 anti-IgA antibodies (the strongest found heterophilic immunoglobulins) are responsible for most artifacts obtained with commercial ELISA systems.

引用

页码：1617 / 1618

页数：2