The ABCA subfamily - gene and protein structures, functions and associated hereditary diseases

被引：82

作者：

Albrecht, Christiane ^{[1
]}

Viturro, Enrique ^{[1
]}

机构：

[1] Tech Univ Munich, Physiol Weihenstephan, D-85354 Freising Weihenstephan, Germany

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2007年 / 453卷 / 05期

关键词：

ATP-binding cassette transporters; lipid transport; full transporters; ABCA subfamily;

D O I：

10.1007/s00424-006-0047-8

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

To date, 12 members of the human ABCA subfamily are identified. They share a high degree of sequence conservation and have been mostly related with lipid trafficking in a wide range of body locations. Mutations in some of these genes have been described to cause severe hereditary diseases related with lipid transport, such as fatal surfactant deficiency or harlequin ichthyosis. In addition, most of them are hypothesized to participate in the subcellular sequestration of drugs, thereby being responsible for the resistance of several carcinoma cell lines against drug treatment. The objective of this review is to summarize the literature for this subfamily of ABC transporter proteins, excluding ABCA1 and ABCA4, which will be discussed in other chapters of this issue.

引用

页码：581 / 589

页数：9

共 57 条

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