Characterization of an integron carrying a new class D β-lactamase (OXA-37) in Acinetobacter baumannii

被引：41

作者：

Navia, MM

Ruiz, J

Vila, J

机构：

[1] Hosp Clin Barcelona, Microbiol Serv, Inst Clin Infecc & Immunol, Barcelona 08036, Spain

[2] Univ Barcelona, IDIBAPS, E-08007 Barcelona, Spain

来源：

MICROBIAL DRUG RESISTANCE | 2002年 / 8卷 / 04期

关键词：

D O I：

10.1089/10766290260469516

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Integrons from a clinical strain of Acinetobacter baumannii highly resistant to beta-lactams have been analyzed. The largest (2.2 kb) contained three gene cassettes: an aacA4, an open reading frame of 417 nucleotides, and an OXA-type encoding gene. The oxa gene nucleotide sequence differed from that of the oxa-20 in 2 bp, one of the mutations being silent. The nonsilent mutation generated a substitution of glutamic acid for aspartic acid. The new OXA has been named OXA-37.

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页码：261 / 265

页数：5

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