Honey bee aggression supports a link between gene regulation and behavioral evolution

被引:219
作者
Alaux, Cedric [1 ,6 ]
Sinha, Saurabh [2 ]
Hasadsri, Linda [3 ]
Hunt, Greg J. [9 ]
Guzman-Novoa, Ernesto [8 ]
DeGrandi-Hoffman, Gloria [10 ]
Luis Uribe-Rubio, Jose [11 ]
Southey, Bruce R. [2 ,4 ]
Rodriguez-Zas, Sandra [5 ,6 ,7 ]
Robinson, Gene E. [1 ,6 ,7 ]
机构
[1] Univ Illinois, Dept Entomol, Urbana, IL 61801 USA
[2] Univ Illinois, Dept Comp Sci, Urbana, IL 61801 USA
[3] Univ Illinois, Dept Cell & Dev Biol, Urbana, IL 61801 USA
[4] Univ Illinois, Dept Chem, Urbana, IL 61801 USA
[5] Univ Illinois, Dept Anim Sci, Urbana, IL 61801 USA
[6] Univ Illinois, Inst Genom Biol, Urbana, IL 61801 USA
[7] Univ Illinois, Program Neurosci, Urbana, IL 61801 USA
[8] Univ Guelph, Dept Environm Biol, Guelph, ON N1G 2W1, Canada
[9] Purdue Univ, Dept Entomol, W Lafayette, IN 47907 USA
[10] USDA ARS, Carl Hayden Bee Res Ctr, Tucson, AZ 85719 USA
[11] Inst Nacl Invest Forestales, Ctr Nacl Invest Fisiol Anim, Ajuchitlan 76280, Qro, Mexico
基金
美国国家卫生研究院;
关键词
DIVISION-OF-LABOR; ALARM PHEROMONE; SOCIAL-BEHAVIOR; DEFENSIVE BEHAVIOR; EXPRESSION; GENOMICS; SEROTONIN; MOTIFS; LOBES;
D O I
10.1073/pnas.0907043106
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
A prominent theory states that animal phenotypes arise by evolutionary changes in gene regulation, but the extent to which this theory holds true for behavioral evolution is not known. Because "nature and nurture'' are now understood to involve hereditary and environmental influences on gene expression, we studied whether environmental influences on a behavioral phenotype, i.e., aggression, could have evolved into inherited differences via changes in gene expression. Here, with microarray analysis of honey bees, we show that aggression-related genes with inherited patterns of brain expression are also environmentally regulated. There were expression differences in the brain for hundreds of genes between the highly aggressive Africanized honey bee compared with European honey bee (EHB) subspecies. Similar results were obtained for EHB in response to exposure to alarm pheromone (which provokes aggression) and when comparing old and young bees (aggressive tendencies increase with age). There was significant overlap of the gene lists generated from these three microarray experiments. Moreover, there was statistical enrichment of several of the same cis regulatory motifs in promoters of genes on all three gene lists. Aggression shows a remarkably robust brain molecular signature regardless of whether it occurs because of inherited, age-related, or environmental (social) factors. It appears that one element in the evolution of different degrees of aggressive behavior in honey bees involved changes in regulation of genes that mediate the response to alarm pheromone.
引用
收藏
页码:15400 / 15405
页数:6
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