Medicinal plants from Nepal:: evaluation as inhibitors of leukotriene biosynthesis

被引：16

作者：

Kumar, S

Ziereis, K

Wiegrebe, W

Müller, K

机构：

[1] Univ Munster, Inst Pharmaceut Chem, D-48149 Munster, Germany

[2] Univ Regensburg, Inst Pharm, D-93040 Regensburg, Germany

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2000年 / 70卷 / 03期

关键词：

antiinflammatory activity; leukotrienes; 5-lipoxygenase; Nepalese plants; traditional medicine;

D O I：

10.1016/S0378-8741(00)00203-8

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The methanolic extracts of 25 different Nepalese medicinal plants were tested for their activity to inhibit the biosynthesis of leukotriene B-4 in bovine polymorphonuclear leukocytes. The selected indigenous plants are used in traditional herb remedies to treat inflammatory diseases such as asthma, bronchitis, rheumatism, and skin disorders presumed to be mediated by leukotrienes. The leaves of Zanthoxylum nepalensis were shown to be the most potent inhibitor with an IC50 value of 11 mu g/ml. The extracts obtained from Astercantha longifolia and Hedychium ellipticum also exhibited potent inhibitory action with IC50 values of 20 and 22 mu g/ml, respectively. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：191 / 195

页数：5

共 17 条

[1] EFFECT OF INHIBITION OF SYNTHESIS AND RECEPTOR ANTAGONISM OF SRS-A IN CARDIAC ANAPHYLAXIS [J].