Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice

被引：1288

作者：

Postic, Catherine ^{[1
,2
]}

Girard, Jean ^{[1
,2
]}

机构：

[1] INSERM, U567, Paris, France

[2] Univ Paris 05, CNRS, UMR 8104, Inst Cochin,Dept Endocrinol Metab & Canc, Paris, France

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2008年 / 118卷 / 03期

关键词：

D O I：

10.1172/JCI34275

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, and type 2 diabetes. NAFLD represents a large spectrum of diseases ranging from (i) fatty liver (hepatic steatosis); (ii) steatosis with inflammation and necrosis; and (iii) cirrhosis. Although the molecular mechanism leading to the development of hepatic steatosis in the pathogenesis of NAFLD is complex, recent animal models have shown that modulating important enzymes in fatty acid synthesis in liver may be key for the treatment of NAFLD. This review discusses recent advances in the field.

引用

页码：829 / 838

页数：10

共 100 条

[1]

Nonalcoholic fatty liver disease as a complication of insulin resistance [J].

Abdelmalek, Manal F. ;

Diehl, Anna Mae .

MEDICAL CLINICS OF NORTH AMERICA, 2007, 91 (06) :1125-+

[2]

Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal [J].

Abu-Elheiga, L ;

Matzuk, MM ;

Kordari, P ;

Oh, W ;

Shaikenov, T ;

Gu, ZW ;

Wakil, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (34) :12011-12016

[3]

Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets [J].

Abu-Elheiga, L ;

Oh, WK ;

Kordari, P ;

Wakil, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (18) :10207-10212

[4]

The subcellular localization of acetyl-CoA carboxylase 2 [J].

Abu-Elheiga, L ;

Brinkley, WR ;

Zhong, L ;

Chirala, SS ;

Woldegiorgis, G ;

Wakil, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (04) :1444-1449

[5]

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2 [J].

Abu-Elheiga, L ;

Matzuk, MM ;

Abo-Hashema, KAH ;

Wakil, SJ .

SCIENCE, 2001, 291 (5513) :2613-2616

[6]

Nonalcoholic fatty liver disease [J].

Adams, Leon A. ;

Lindor, Keith D. .

ANNALS OF EPIDEMIOLOGY, 2007, 17 (11) :863-869

[7]

Modulation of sterol regulatory element binding proteins (SREBPs) as potential treatments for non-alcoholic fatty liver disease (NAFLD) [J].

Ahmed, Mohamed H. ;

Byrne, Christopher D. .

DRUG DISCOVERY TODAY, 2007, 12 (17-18) :740-747

[8]

A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis [J].

Belfort, Renata ;

Harrison, Stephen A. ;

Brown, Kenneth ;

Darland, Celia ;

Finch, Joan ;

Hardies, Jean ;

Balas, Bogdan ;

Gastaldelli, Amalia ;

Tio, Fermin ;

Pulcini, Joseph ;

Berria, Rachele ;

Ma, Jennie Z. ;

Dwivedi, Sunil ;

Havranek, Russell ;

Fincke, Chris ;

DeFronzo, Ralph ;

Bannayan, George A. ;

Schenker, Steven ;

Cusi, Kenneth .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (22) :2297-2307

[9]

Preserved direct hepatic insulin action in rats with diet-induced hepatic steatosis [J].

Buettner, R ;

Ottinger, I ;

Schölmerich, J ;

Bollheimer, LC .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2004, 286 (05) :E828-E833

[10]

The OB protein (leptin) pathway - A link between adipose tissue mass and central neural networks [J].

Campfield, LA ;

Smith, FJ ;

Burn, P .

HORMONE AND METABOLIC RESEARCH, 1996, 28 (12) :619-632

← 1 2 3 4 5 6 7 8 9 10 →