Normative values for carotid intima media thickness and its progression: Are they transferrable outside of their cohort of origin?

被引：33

作者：

Liao, Ximing ^{[1
]}

Norata, Giuseppe D. ^{[2
,3
]}

Polak, Joseph F. ^{[4
]}

Stehouwer, Coen D. A. ^{[5
,6
]}

Catapano, Alberico ^{[7
,8
]}

Rundek, Tatjana ^{[9
]}

Ezhov, Marat ^{[10
]}

Sander, Dirk ^{[11
,12
]}

Thompson, Simon G. ^{[13
]}

Lorenz, Matthias W. ^{[1
]}

Balakhonova, Tatyana ^{[14
]}

Safarova, Maya ^{[10
]}

Grigore, Liliana ^{[3
]}

Empana, Jean-Philippe ^{[15
]}

Lin, Hung-Ju ^{[16
]}

McLachlan, Stela ^{[17
]}

Bokemark, Lena ^{[18
]}

Ronkainen, Kimmo ^{[19
]}

Schminke, Ulf ^{[20
]}

Lind, Lars ^{[21
]}

Willeit, Peter ^{[13
,22
]}

Yanez, David N. ^{[23
]}

Steinmetz, Helmuth ^{[1
]}

Poppert, Holger ^{[12
]}

Desvarieux, Moise ^{[24
]}

Ikram, M. Arfan ^{[25
,26
,27
]}

Johnsen, Stein Harald ^{[28
,29
]}

Iglseder, Bernhard ^{[30
,31
]}

Friera, Alfonsa ^{[32
]}

Xie, Wuxiang ^{[33
]}

Plichart, Matthieu ^{[34
]}

Su, Ta-Chen ^{[16
]}

Srinivasan, Sathanur R. ^{[35
]}

Schmidt, Caroline ^{[18
]}

Tuomainen, Tomi-Pekka ^{[19
]}

Volzke, Henry ^{[36
]}

Nijpels, Giel ^{[37
,38
,39
]}

Willeit, Johann ^{[22
]}

Franco, Oscar H. ^{[25
]}

Suarez, Carmen

Zhao, Dong ^{[33
]}

Ducimetiere, Pierre ^{[40
]}

Chien, Kuo-Liong ^{[41
]}

Robertson, Christine ^{[17
]}

Bergstrom, Goran ^{[18
]}

Kauhanen, Jussi ^{[19
]}

Dorr, Marcus ^{[42
,43
]}

Dekker, Jaqueline M. ^{[44
]}

Kiechl, Stefan ^{[22
]}

Sitzer, Matthias ^{[1
,45
]}

机构：

[1] Goethe Univ Frankfurt, Dept Neurol, Frankfurt, Germany

[2] Univ Milan, Dipartimento Sci Farmacol & Biomol, I-20122 Milan, Italy

[3] Bassini Hosp, SISA Ctr Study Atherosclerosis, Cinisello Balsamo, Italy

[4] Tufts Univ, Sch Med, Tufts Med Ctr, Boston, MA 02111 USA

[5] Maastricht Univ, Dept Internal Med, Med Ctr, NL-6200 MD Maastricht, Netherlands

[6] Maastricht Univ, Cardiovasc Res Inst Maastricht CARIM, Med Ctr, NL-6200 MD Maastricht, Netherlands

[7] IRCSS Multimed, Milan, Italy

[8] Univ Milan, Dept Pharmacol & Biomol Sci, I-20122 Milan, Italy

[9] Univ Miami, Miller Sch Med, Dept Neurol, Coral Gables, FL 33124 USA

[10] Cardiol Res Ctr, Atherosclerosis Dept, Moscow, Russia

[11] Benedictus Hosp Tutzing & Feldafing, Dept Neurol, Feldafing, Germany

[12] Tech Univ Munich, Dept Neurol, D-80290 Munich, Germany

[13] Univ Cambridge, Dept Publ Hlth & Primary Care, Sch Clin Med, Cambridge CB2 1TN, England

[14] Cardiol Res Ctr 2, Ultrasound Vasc Lab, Moscow, Russia

[15] Univ Paris 05, Sorbonne Paris Cite, Paris Cardiovasc Res Ctr PARCC, Paris, France

[16] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan

[17] Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh EH8 9YL, Midlothian, Scotland

[18] Gothenburg Univ, Wallenberg Lab Cardiovasc Res, Inst Medicin, Dept Mol & Clin Med,Sahlgrenska Acad, S-41124 Gothenburg, Sweden

[19] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland

[20] Greifswald Univ Clin, Dept Neurol, Greifswald, Germany

[21] Uppsala Univ, Dept Med, Uppsala, Sweden

[22] Med Univ Innsbruck, Dept Neurol, Innsbruck, Austria

[23] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[24] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA

[25] Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands

[26] Erasmus Univ, Med Ctr, Dept Neurol, Rotterdam, Netherlands

[27] Erasmus Univ, Med Ctr, Dept Radiol, Rotterdam, Netherlands

[28] Univ Tromso, Dept Clin Med, N-9001 Tromso, Norway

[29] Univ Hosp Northern Norway, Dept Neurol, Tromso, Norway

[30] Parcelsus Med Univ, Salzburg, Austria

[31] Gemeinnutzige Salzburger Landeskliniken Betriebse, Christian Doppler Klin, Dept Geriatr Med, Salzburg, Austria

[32] Univ Autonoma Madrid, Dept Radiol, Hosp Univ Princesa, E-28049 Madrid, Spain

[33] Capital Med Univ, Dept Epidemiol, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing Anzhen Hosp, Beijing, Peoples R China

[34] Hop Broca, AP HP, Paris, France

[35] Tulane Univ, Sch Publ Hlth & Trop Med, Ctr Cardiovasc Hlth, Dept Epidemiol,Biochem, New Orleans, LA USA

[36] SHIP Clin Epidemiol Res, Inst Community Med, Greifswald, Germany

[37] Vrije Univ Amsterdam, Med Ctr, Dept Gen Practice, Amsterdam, Netherlands

[38] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands

[39] Univ Autonoma Madrid, Dept Internal Med, Hosp Univ Princesa, E-28049 Madrid, Spain

[40] Univ Paris 11, Le Kremlin Bicetre, France

[41] Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei, Taiwan

[42] Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany

[43] Partner Site Greifswald, German Ctr Cardiovasc Res DZHK, Greifswald, Germany

[44] Univ Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands

[45] Klinikum Herford, Dept Neurol, Herford, Germany

[46] Tech Univ Munich, Dept Psychiat & Psychotherapy, D-80290 Munich, Germany

[47] Hosp Univ La Paz, Inst Invest IdiPAZ, Madrid, Spain

[48] Tulane Univ, Sch Med, Dept Med, Pediat,Biochem,Epidemiol, 1430 Tulane Ave, New Orleans, LA 70112 USA

[49] Tulane Univ, Sch Publ Hlth & Trop Med, New Orleans, LA USA

[50] Erasmus MC, Dept Epidemiol & Biostat, Rotterdam, Netherlands

来源：

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY | 2016年 / 23卷 / 11期

关键词：

Intima media thickness; normal value; ethnicity; geographic; hazard ratio; cardiovascular risk; CARDIOVASCULAR RISK; ATHEROSCLEROSIS RISK; DISEASE RISK; POPULATION; PREDICTION; METAANALYSIS; ULTRASOUND; IDENTIFY; EVENTS;

D O I：

10.1177/2047487315625543

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Background The clinical use of carotid intima media thickness (cIMT) requires normal values, which may be subject to variation of geographical factors, ethnicity or measurement details. The influence of these factors has rarely been studied. The aim of this study was to determine whether normative cIMT values and their association with event risk are generalizable across populations. Design Meta-analysis of individual participant data. Method From 22 general population cohorts from Europe, North America and Asia we selected subjects free of cardiovascular disease. Percentiles of cIMT and cIMT progression were assessed separately for every cohort. Cox proportional hazards models for vascular events were used to estimate hazard ratios for cIMT in each cohort. The estimates were pooled across Europe, North America and Asia, with random effects meta-analysis. The influence of geography, ethnicity and ultrasound protocols on cIMT values and on the hazard ratios was examined by meta-regression. Results Geographical factors, ethnicity and the ultrasound protocol had influence neither on the percentiles of cIMT and its progression, nor on the hazard ratios of cIMT for vascular events. Heterogeneity for percentiles of cIMT and cIMT progression was too large to create meaningful normative values. Conclusions The distribution of cIMT values is too heterogeneous to define universal or regional population reference values. CIMT values vary widely between different studies regardless of ethnicity, geographic location and ultrasound protocol. Prediction of vascular events with cIMT values was more consistent across all cohorts, ethnicities and regions.

引用

页码：1165 / 1173

页数：9

共 24 条

[1]

[Anonymous], 2005, P 30 ANN SAS US GROU

[2]

Cross-sectional analysis of baseline data to identify the major determinants of carotid intima-media thickness in a European population: the IMPROVE study [J].

Baldassarre, Damiano ;

Nyyssonen, Kristiina ;

Rauramaa, Rainer ;

de Faire, Ulf ;

Hamsten, Anders ;

Smit, Andries J. ;

Mannarino, Elmo ;

Humphries, Steve E. ;

Giral, Philippe ;

Grossi, Enzo ;

Veglia, Fabrizio ;

Paoletti, Rodolfo ;

Tremoli, Elena .

EUROPEAN HEART JOURNAL, 2010, 31 (05) :614-622

[3]

Carotid ultrasound examination as an aging and disability marker [J].

Barrera, Gladys ;

Bunout, Daniel ;

Pia de la Maza, Maria ;

Leiva, Laura ;

Hirsch, Sandra .

GERIATRICS & GERONTOLOGY INTERNATIONAL, 2014, 14 (03) :710-715

[4]

Common Carotid Intima-Media Thickness Measurements Do Not Improve Cardiovascular Risk Prediction in Individuals With Elevated Blood Pressure The USE-IMT Collaboration [J].

Bots, Michiel L. ;

Groenewegen, Karlijn A. ;

Anderson, Todd J. ;

Britton, Annie R. ;

Dekker, Jacqueline M. ;

Engstrom, Gunnar ;

Evans, Greg W. ;

de Graaf, Jacqueline ;

Grobbee, Diederick E. ;

Hedblad, Bo ;

Hofman, Albert ;

Holewijn, Suzanne ;

Ikeda, Ai ;

Kavousi, Maryam ;

Kitagawa, Kazuo ;

Kitamura, Akihiko ;

Ikram, M. Arfan ;

Lonn, Eva M. ;

Lorenz, Matthias W. ;

Mathiesen, Ellisiv B. ;

Nijpels, Giel ;

Okazaki, Shuhei ;

O'Leary, Daniel H. ;

Polak, Joseph F. ;

Price, Jacqueline F. ;

Robertson, Christine ;

Rembold, Christopher M. ;

Rosvall, Maria ;

Rundek, Tatjana ;

Salonen, Jukka T. ;

Sitzer, Matthias ;

Stehouwer, Coen D. A. ;

Franco, Oscar H. ;

Peters, Sanne A. E. ;

den Ruijter, Hester M. .

HYPERTENSION, 2014, 63 (06) :1173-1181

[5]

Variability in the intima-media thickness measurement as marker for cardiovascular risk? Not quite settled yet [J].

Bots, Michiel L. ;

den Ruijter, Hester M. .

CARDIOVASCULAR DIAGNOSIS AND THERAPY, 2012, 2 (01) :3-5

[6]

Carotid artery intima-media thickness: normal and percentile values in the Italian population (camp study) [J].

Ciccone, Marco Matteo ;

Balbarini, Alberto ;

Porcelli, Maria Teresa ;

Santoro, Daniela ;

Cortese, Francesca ;

Scicchitano, Pietro ;

Favale, Stefano ;

Butitta, Flavio ;

De Pergola, Giovanni ;

Gullace, Giuseppe ;

Novo, Salvatore .

EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION, 2011, 18 (04) :650-655

[7]

Use of carotid intima-media thickness regression to guide therapy and management of cardiac risks [J].

Costanzo P. ;

Cleland J.G. ;

Atkin S.L. ;

Vassallo E. ;

Perrone-Filardi P. .

Current Treatment Options in Cardiovascular Medicine, 2012, 14 (1) :50-56

[8]

Common carotid intima-media thickness does not add to Framingham risk score in individuals with diabetes mellitus: the USE-IMT initiative [J].

den Ruijter, H. M. ;

Peters, S. A. E. ;

Groenewegen, K. A. ;

Anderson, T. J. ;

Britton, A. R. ;

Dekker, J. M. ;

Engstrom, G. ;

Eijkemans, M. J. ;

Evans, G. W. ;

de Graaf, J. ;

Grobbee, D. E. ;

Hedblad, B. ;

Hofman, A. ;

Holewijn, S. ;

Ikeda, A. ;

Kavousi, M. ;

Kitagawa, K. ;

Kitamura, A. ;

Koffijberg, H. ;

Ikram, M. A. ;

Lonn, E. M. ;

Lorenz, M. W. ;

Mathiesen, E. B. ;

Nijpels, G. ;

Okazaki, S. ;

O'Leary, D. H. ;

Polak, J. F. ;

Price, J. F. ;

Robertson, C. ;

Rembold, C. M. ;

Rosvall, M. ;

Rundek, T. ;

Salonen, J. T. ;

Sitzer, M. ;

Stehouwer, C. D. A. ;

Witteman, J. C. ;

Moons, K. G. ;

Bots, M. L. .

DIABETOLOGIA, 2013, 56 (07) :1494-1502

[9]

Common Carotid Intima-Media Thickness Measurements in Cardiovascular Risk Prediction A Meta-analysis [J].

Den Ruijter, Hester M. ;

Peters, Sanne A. E. ;

Anderson, Todd J. ;

Britton, Annie R. ;

Dekker, Jacqueline M. ;

Eijkemans, Marinus J. ;

Engstrom, Gunnar ;

Evans, Gregory W. ;

de Graaf, Jacqueline ;

Grobbee, Diederick E. ;

Hedblad, Bo ;

Hofman, Albert ;

Holewijn, Suzanne ;

Ikeda, Ai ;

Kavousi, Maryam ;

Kitagawa, Kazuo ;

Kitamura, Akihiko ;

Koffijberg, Hendrik ;

Lonn, Eva M. ;

Lorenz, Matthias W. ;

Mathiesen, Ellisiv B. ;

Nijpels, Giel ;

Okazaki, Shuhei ;

O'Leary, Daniel H. ;

Polak, Joseph F. ;

Price, Jackie F. ;

Robertson, Christine ;

Rembold, Christopher M. ;

Rosvall, Maria ;

Rundek, Tatjana ;

Salonen, Jukka T. ;

Sitzer, Matthias ;

Stehouwer, Coen D. A. ;

Witteman, Jacqueline C. ;

Moons, Karel G. ;

Bots, Michiel L. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 308 (08) :796-803

[10]

METAANALYSIS IN CLINICAL-TRIALS [J].

DERSIMONIAN, R ;

LAIRD, N .

CONTROLLED CLINICAL TRIALS, 1986, 7 (03) :177-188

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