p53 mutation is associated with high S-phase fraction in primary fallopian tube adenocarcinoma

被引：14

作者：

Runnebaum, IB

Kohler, T

Stickeler, E

Rosenthal, HE

Kieback, DG

Kreienberg, R

机构：

[1] Dept. of Obstetrics and Gynaecology, Molecular Biology Laboratory, University of Ulm

[2] Dept. of Obstetrics and Gynaecology, Frauenklinik, University of Ulm, 89075 Ulm

来源：

BRITISH JOURNAL OF CANCER | 1996年 / 74卷 / 08期

关键词：

fallopian tube cancer; p53; mutation; cell cycle; human papilloma virus (HPV);

D O I：

10.1038/bjc.1996.510

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fallopian tube carcinoma (FTC) is a rare but lethal gynaecological malignancy. Four out of seven FTCs were identified with three point missense mutations, one single base deletion and one silent point mutation in the p53 gene. Genital-type HPV sequences were not detected. The S-phase fraction of tumours with mutant and wild-type p53 was 25.74% (median) and 12.55% (median) respectively.

引用

收藏

页码：1157 / 1160

页数：4

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